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The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.新型脂肪因子C1q-肿瘤坏死因子相关蛋白9（CTRP9）在系统性硬化症相关间质性肺疾病中升高。
Clin Exp Rheumatol. 2018 Jul-Aug;36 Suppl 113(4):184-185. Epub 2018 Aug 28.
2
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Elevated Serum Krebs von den Lungen-6 in Early Disease Predicts Subsequent Deterioration of Pulmonary Function in Patients with Systemic Sclerosis and Interstitial Lung Disease.疾病早期血清克雷伯斯-冯-登-伦根-6升高可预测系统性硬化症和间质性肺病患者随后的肺功能恶化。
J Rheumatol. 2016 Oct;43(10):1825-1831. doi: 10.3899/jrheum.160339. Epub 2016 Aug 1.
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Tumour-associated antigens in systemic sclerosis patients with interstitial lung disease: association with lung involvement and cancer risk.系统性硬化症伴间质性肺病患者的肿瘤相关抗原：与肺部受累和癌症风险的关联。
Rheumatology (Oxford). 2015 Nov;54(11):1991-9. doi: 10.1093/rheumatology/kev204. Epub 2015 Jun 22.
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Elevated serum Krebs von den Lungen-6 in systemic sclerosis: a marker of lung fibrosis and severity of the disease.血清 Krebs von den Lungen-6 水平升高与系统性硬化症：肺纤维化和疾病严重程度的标志物。
Rheumatol Int. 2018 May;38(5):813-819. doi: 10.1007/s00296-018-3987-3. Epub 2018 Feb 17.
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Circulating C1q complement/TNF-related protein (CTRP) 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucose.2型糖尿病患者循环中C1q补体/TNF相关蛋白（CTRP）1、CTRP9、CTRP12和CTRP13的浓度：葡萄糖的体内调节作用
PLoS One. 2017 Feb 16;12(2):e0172271. doi: 10.1371/journal.pone.0172271. eCollection 2017.
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Performance of Candidate Serum Biomarkers for Systemic Sclerosis-Associated Interstitial Lung Disease.候选血清生物标志物在系统性硬化症相关间质性肺病中的表现。
Arthritis Rheumatol. 2019 Jun;71(6):972-982. doi: 10.1002/art.40815. Epub 2019 Apr 26.
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Circulating CTRP9 Is Associated With Severity of Systemic Sclerosis-Associated Interstitial Lung Disease.循环 CTRP9 与系统性硬化症相关的间质性肺病的严重程度相关。
Arthritis Care Res (Hoboken). 2023 Jan;75(1):152-157. doi: 10.1002/acr.24749. Epub 2022 Aug 24.
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Interleukin-17 and interleukin-23: importance in the pathogenesis of lung impairment in patients with systemic sclerosis.白细胞介素-17与白细胞介素-23：在系统性硬化症患者肺损伤发病机制中的重要性
Int J Rheum Dis. 2014 Jul;17(6):664-70. doi: 10.1111/1756-185X.12290. Epub 2014 Jan 28.
10
Interstitial lung disease as the first manifestation of systemic sclerosis.间质性肺病作为系统性硬化症的首发表现
Neth J Med. 2007 Nov;65(10):390-4.

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1
C1q/Tumor Necrosis Factor-Related Protein 9: Basics and Therapeutic Potentials.C1q/肿瘤坏死因子相关蛋白9：基础与治疗潜力
Front Physiol. 2022 Mar 18;13:816218. doi: 10.3389/fphys.2022.816218. eCollection 2022.
2
Role of adipokines in systemic sclerosis pathogenesis.脂肪因子在系统性硬化症发病机制中的作用。
Eur J Rheumatol. 2020 Oct;7(Suppl 3):S165-S172. doi: 10.5152/eurjrheum.2020.19107. Epub 2020 Jul 6.

本文引用的文献

1
CCL2 in the Circulation Predicts Long-Term Progression of Interstitial Lung Disease in Patients With Early Systemic Sclerosis: Data From Two Independent Cohorts.循环中 CCL2 可预测早期系统性硬化症患者间质性肺病的长期进展：来自两个独立队列的数据。
Arthritis Rheumatol. 2017 Sep;69(9):1871-1878. doi: 10.1002/art.40171. Epub 2017 Aug 8.
2
Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction.血浆C1q/TNF相关蛋白9水平与无肾功能不全的2型糖尿病患者的动脉粥样硬化相关。
J Diabetes Res. 2016;2016:8624313. doi: 10.1155/2016/8624313. Epub 2016 Dec 14.
3
C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure.C1q-TNF 相关蛋白 9 促进心肌肥大和衰竭。
Circ Res. 2017 Jan 6;120(1):66-77. doi: 10.1161/CIRCRESAHA.116.309398. Epub 2016 Nov 7.
4
A brief glimpse at CTRP3 and CTRP9 in lipid metabolism and cardiovascular protection.简要观察 CTRP3 和 CTRP9 在脂代谢和心血管保护中的作用。
Prog Lipid Res. 2016 Oct;64:170-177. doi: 10.1016/j.plipres.2016.10.001. Epub 2016 Oct 12.
5
Systemic sclerosis.系统性硬化症。
Nat Rev Dis Primers. 2015 Apr 23;1:15002. doi: 10.1038/nrdp.2015.2.
6
C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells.C1q/TNF相关蛋白9通过激活内皮细胞中的AMP活化蛋白激酶来抑制细胞因子诱导的血管炎症和白细胞黏附。
Mol Cell Endocrinol. 2016 Jan 5;419:235-43. doi: 10.1016/j.mce.2015.10.023. Epub 2015 Oct 31.
7
Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment.系统性硬化症生物标志物的最新进展：诊断与治疗工具
Semin Immunopathol. 2015 Sep;37(5):475-87. doi: 10.1007/s00281-015-0506-4. Epub 2015 Jul 14.
8
Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors.脂肪细胞衍生素阳性真皮内祖细胞可分化为小鼠皮肤纤维化中的肌成纤维细胞。
Arthritis Rheumatol. 2015 Apr;67(4):1062-73. doi: 10.1002/art.38990.
9
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin.从脂肪组织中鉴定并表征新型分泌糖蛋白CTRP9，其可降低小鼠血清葡萄糖水平并与脂联素形成异源三聚体。
FASEB J. 2009 Jan;23(1):241-58. doi: 10.1096/fj.08-114991. Epub 2008 Sep 11.
10
Scleroderma (systemic sclerosis): classification, subsets and pathogenesis.硬皮病（系统性硬化症）：分类、亚型及发病机制
J Rheumatol. 1988 Feb;15(2):202-5.

The novel adipokine C1q-TNF related protein 9 (CTRP9) is elevated in systemic sclerosis-associated interstitial lung disease.

作者信息

Korman Benjamin, Alejo Rafael, Sudhakar Deepshika, Hinchcliff Monique, Agrawal Rishi, Varga John, Marangoni Roberta G

机构信息

Northwestern Scleroderma Program, Departments of Medicine and Dermatology, Division of Rheumatology, Northwestern University, Chicago, IL, USA.

Northwestern Scleroderma Program,Departments of Medicine and Dermatology, Division of Rheumatology, Northwestern University, Chicago, IL, USA.

出版信息

Clin Exp Rheumatol. 2018 Jul-Aug;36 Suppl 113(4):184-185. Epub 2018 Aug 28.

PMID:30183591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7389309/
Abstract
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