Wang Zhongwen, Sparling Melissa, Tague Brett
a Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Product and Food Branch , Health Canada , Ottawa , Canada.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Oct;35(10):2022-2031. doi: 10.1080/19440049.2018.1508891. Epub 2018 Sep 6.
In order to determine the baseline levels of perchlorate in major brands of baby food, 200 baby food products were collected from retail stores in Ottawa, Canada and analysed for perchlorate in 2010. The seven food groups tested were fruit, juices, vegetables, meat, yogurt, mixed (vegetable mixed with meat) and other (e.g. vegetable mixed with meat and cereal, cheese, egg,). Samples were extracted with a mixture of methanol and 1% acetic acid (4:1, v/v). Determination was conducted by stable isotope dilution ion chromatography tandem mass spectrometry (ID-IC-MS/MS). The complexity of different food matrices required additional method validation. The perchlorate levels in 46 samples were found to be lower than the quantification limit (0.2 ng g). The perchlorate levels in the other 154 baby food samples were also low; about 96.7% of the baby foods had perchlorate levels less than 10 ng g (ranged from 0.2 to 22.4 ng g, median1.35 ng g); only 5 samples had perchlorate levels higher than 10 ng g. Dietary exposure to perchlorate from analysed baby food was conservatively estimated to range from 0.007 to 0.121 µg/kg bw/d based on the mean intake for children (1-5 years old).
为了确定主要品牌婴儿食品中高氯酸盐的基线水平，2010年从加拿大渥太华的零售店收集了200种婴儿食品产品，并对其进行了高氯酸盐分析。测试的七类食品分别是水果、果汁、蔬菜、肉类、酸奶、混合类（蔬菜与肉类混合）和其他类（如蔬菜与肉类和谷物混合、奶酪、鸡蛋等）。样品用甲醇和1%乙酸的混合物（4:1，v/v）进行萃取。采用稳定同位素稀释离子色谱串联质谱法（ID-IC-MS/MS）进行测定。不同食品基质的复杂性需要进行额外的方法验证。发现46个样品中的高氯酸盐水平低于定量限（0.2 ng/g）。其他154个婴儿食品样品中的高氯酸盐水平也很低；约96.7%的婴儿食品中高氯酸盐水平低于10 ng/g（范围为0.2至22.4 ng/g，中位数为1.35 ng/g）；只有5个样品的高氯酸盐水平高于10 ng/g。根据1至5岁儿童平均摄入量，经分析的婴儿食品中高氯酸盐的膳食暴露量保守估计为0.007至0.121 μg/kg bw/d。
