Garg Suruchi, Dosapaty Namrata, Arora Amanjot Kaur
*All authors are affiliated with the Department of Dermatology, Aesthetic Surgery, and Intervention Dermatology, Aura Skin Institute, Chandigarh, India.
All authors are affiliated with the Department of Dermatology, Aesthetic Surgery, and Intervention Dermatology, Aura Skin Institute, Chandigarh, India.
Dermatol Surg. 2019 Jan;45(1):83-89. doi: 10.1097/DSS.0000000000001641.
Noncultured epidermal cell suspension transplantation is a very popular surgical modality for treating vitiligo. However, the procedure can be modified to improve results.
To study the extent of repigmentation with noncultured trypsinized fragmented epidermal suspension using platelet-rich plasma (PRP) as a suspending agent and pixel erbium yttrium aluminium garnet laser for ablation of recipient area in patients with stable vitiligo.
Autologous noncultured tiny epidermal fragments suspended in PRP were grafted on superficially pixel erbium YAG laser-ablated vitiligo lesions in 10 patients. The repigmentation was evaluated over a period of 6 months using a digital image analysis system.
Repigmentation was observed as early as 2 weeks after the treatment. Of 20 lesions, 12 (60%) showed excellent response; of which 10 lesions (50%) showed complete repigmentation in 8 weeks only. There were no milia or keloid formation, donor-site scarring, stuck on appearance at recipient site or infection.
This study indicates that PRP-enriched epidermal suspension transplant (LA-PEEST) has the potential to improve the rate of healing and repigmentation in vitiligo patches. Further investigations and larger controlled trials are required to establish this technique as a rapid surgical method to restore pigmentation.
非培养表皮细胞悬液移植是治疗白癜风非常流行的一种手术方式。然而，该手术可进行改进以提高疗效。
研究在稳定期白癜风患者中，使用富含血小板血浆（PRP）作为悬浮剂的非培养胰蛋白酶消化破碎表皮悬液以及像素铒钇铝石榴石激光对受区进行磨削后色素再生的程度。
将自体非培养微小表皮碎片悬浮于PRP中，移植到10例患者经像素铒钇铝石榴石激光浅表磨削的白癜风皮损上。使用数字图像分析系统在6个月的时间内评估色素再生情况。
治疗后2周即观察到色素再生。20处皮损中，12处（60%）显示出极佳反应；其中10处皮损（50%）仅在8周内就实现了完全色素再生。未出现粟丘疹或瘢痕疙瘩形成、供区瘢痕、受区外观黏附或感染情况。
本研究表明，富含PRP的表皮悬液移植（LA - PEEST）有提高白癜风皮损愈合和色素再生率的潜力。需要进一步研究和更大规模的对照试验，以确立该技术作为恢复色素沉着的快速手术方法。
