Unit of Dermatology, IRCCS, Ospedale San Raffaele, Milan, Italy.
Dermatology Unit, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Rome, Italy.
Drug Des Devel Ther. 2020 May 7;14:1749-1755. doi: 10.2147/DDDT.S239912. eCollection 2020.
Vitiligo is an acquired, idiopathic disorder clinically characterized by amelanotic lesions on the skin which cause significant impairment of patients' quality of life. A variety of treatments have been proposed, with inconsistent results. In the last decades, the use of platelet-rich plasma (PRP) is receiving increasing interest as a potential effective technique in the treatment of several dermatological diseases, including vitiligo.
We conducted a review with the aim to identify studies that documented the use of PRP for vitiligo.
Electronic databases of MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to November 2019 have been searched using different combinations of the following terms: "platelet-rich plasma", "platelet gel", "platelet-rich fibrin", "PRP" and "vitiligo".
We identified 6 clinical studies consistent with our research, with a total of 253 patients, listing and discussing the obtained results. In all reports, all treated patients showed a stable vitiligo, and a significantly higher improvement in the PRP groups was always observed compared to control groups. Regarding the side effects, PRP in vitiligo patients is useful and without important side effects.
PRP is a promising treatment for stable vitiligo lesions in different body sites. The possible use of PRP in combination with traditional therapeutic options and the standardization of processing protocols represents a very fertile field for future research. Larger clinical trials with longer time of observation would provide solid evidence regarding the effectiveness of PRP for the treatment of vitiligo.
白癜风是一种获得性、特发性疾病，临床上表现为皮肤的非色素性病变，导致患者的生活质量显著受损。已经提出了多种治疗方法，但结果不一致。在过去的几十年中，富血小板血浆（PRP）的应用作为治疗几种皮肤科疾病（包括白癜风）的潜在有效技术越来越受到关注。
我们进行了一项综述，旨在确定记录 PRP 治疗白癜风的研究。
使用 MEDLINE、EMBASE 和 Cochrane 对照试验中心注册库（CENTRAL）的电子数据库，从建立到 2019 年 11 月，使用以下术语的不同组合进行了搜索：“富血小板血浆”、“血小板凝胶”、“富血小板纤维蛋白”、“PRP”和“白癜风”。
我们确定了 6 项符合我们研究的临床研究，共有 253 名患者，列出并讨论了获得的结果。在所有报告中，所有接受治疗的患者的白癜风都稳定，PRP 组的改善总是明显高于对照组。关于副作用，PRP 对白癜风患者是有用的，没有重要的副作用。
PRP 是治疗不同部位稳定白癜风病变的有前途的方法。PRP 与传统治疗选择联合使用以及处理方案的标准化代表了未来研究的一个非常有前途的领域。具有更长观察时间的更大规模临床试验将为 PRP 治疗白癜风的有效性提供确凿证据。
