Nielsen H, Kharazmi A, Faber V
Scand J Immunol. 1986 Sep;24(3):291-6. doi: 10.1111/j.1365-3083.1986.tb02096.x.
The acquired immune deficiency syndrome (AIDS) is characterized by infections with microorganisms against which phagocytes (especially monocytes/macrophages) play an important role. Therefore, various functions of blood monocytes and neutrophils were tested in 16 patients with AIDS. Neutrophil chemotactic responses towards casein and N-formyl-methionyl-L-leucyl-L-phenylalanine were depressed in patients with a short duration of disease (n = 9), whereas they were normal in those with a longer duration (n = 5), P less than 0.05. Neutrophil superoxide anion release was normal. In contrast, we found no evidence of an altered monocyte activity in the patients, since chemotactic responsiveness, phagocytosis of opsonized Candida albicans, and superoxide anion release were all normal. These findings suggest that the depressed neutrophil chemotaxis may play an important role in the high incidence of opportunistic infections in AIDS. Furthermore, it appears that in AIDS the immune deficiency does not extend to peripheral blood monocytes, but it does not exclude the possibility that the function of tissue macrophages is abnormal.
获得性免疫缺陷综合征（艾滋病）的特征是感染一些微生物，而吞噬细胞（尤其是单核细胞/巨噬细胞）在抵御这些微生物方面发挥着重要作用。因此，我们对16例艾滋病患者的血液单核细胞和中性粒细胞的各种功能进行了检测。病程较短的患者（n = 9）对酪蛋白和N-甲酰甲硫氨酰-L-亮氨酰-L-苯丙氨酸的中性粒细胞趋化反应降低，而病程较长的患者（n = 5）的趋化反应正常，P < 0.05。中性粒细胞超氧阴离子释放正常。相比之下，我们在这些患者中未发现单核细胞活性改变的证据，因为趋化反应性、调理素化白色念珠菌的吞噬作用以及超氧阴离子释放均正常。这些发现表明，中性粒细胞趋化性降低可能在艾滋病机会性感染的高发生率中起重要作用。此外，在艾滋病中免疫缺陷似乎并未扩展至外周血单核细胞，但这并不排除组织巨噬细胞功能异常的可能性。
