Antonaci S, Jirillo E, Ventura M T, Garofalo A R, Bonomo L
Mech Ageing Dev. 1984 Mar;24(3):367-75. doi: 10.1016/0047-6374(84)90121-0.
Peripheral blood monocytes obtained from 55 aged donors were evaluated for their chemotactic and phagocytic capacity. In the same subjects, polymorphonuclear cell-mediated functions were studied by chemotaxis, phagocytosis, nylon fiber adherence and nitroblue-tetrazolium reduction assay. Monocytes showed a normal chemotactic responsiveness to zymosan-activated serum, while the chemotactic activity induced by leukocyte-derived chemotactic factor and phagocytosis were rather depressed. A dramatic impairment of polymorphonuclear cell-mediated immune response was also observed. In fact, in spite of a normal nylon fiber adherence, chemotaxis, phagocytosis and nitroblue-tetrazolium reduction capacity were significantly depressed by the aging process. These data suggest that the deficiency of non-specific immunity may play an important role in the increased susceptibility to infections in aged donors.
对从55名老年供体获取的外周血单核细胞的趋化和吞噬能力进行了评估。在相同受试者中，通过趋化性、吞噬作用、尼龙纤维黏附及硝基蓝四唑还原试验研究了多形核细胞介导的功能。单核细胞对酵母聚糖激活的血清表现出正常的趋化反应性，而由白细胞衍生趋化因子诱导的趋化活性和吞噬作用则相当低下。还观察到多形核细胞介导的免疫反应有显著损害。事实上，尽管尼龙纤维黏附正常，但趋化性、吞噬作用和硝基蓝四唑还原能力在衰老过程中显著降低。这些数据表明，非特异性免疫缺陷可能在老年供体对感染易感性增加中起重要作用。
