肝细胞癌中脂肪酸代谢失调
Dysregulated fatty acid metabolism in hepatocellular carcinoma.
作者信息
Wang Mingda, Han Jun, Xing Hao, Zhang Han, Li Zhenli, Liang Lei, Li Chao, Dai Shuyang, Wu Mengchao, Shen Feng, Yang Tian
机构信息
Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Department of Hepatic Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China.
出版信息
Hepat Oncol. 2016 Oct;3(4):241-251. doi: 10.2217/hep-2016-0012. Epub 2017 Jun 30.
Abstract
Hepatocellular carcinoma (HCC) is one of the most frequent and deadly malignancies worldwide. Studies are urgently needed on its molecular pathogenesis and biological characteristics. Dysregulation of fatty acid (FA) metabolism, in which aberrant activation of oncogenic signaling pathways alters the expression and activity of lipid-metabolizing enzymes, is an emerging hallmark of cancer cells, and it may be involved in HCC development and progression. The current review summarizes what is known about dysregulated FA metabolism in HCC and pathways through which this dysregulation may regulate HCC survival and growth. Our understanding of dysregulated FA metabolism and associated signaling pathways may contribute to the development of novel and efficient antitumor approaches for patients with HCC.
摘要
肝细胞癌（HCC）是全球最常见且致命的恶性肿瘤之一。迫切需要对其分子发病机制和生物学特性进行研究。脂肪酸（FA）代谢失调，即致癌信号通路的异常激活改变了脂质代谢酶的表达和活性，是癌细胞的一个新特征，可能参与了HCC的发生和发展。本综述总结了目前已知的HCC中脂肪酸代谢失调的情况以及这种失调可能调节HCC存活和生长的途径。我们对脂肪酸代谢失调及相关信号通路的理解可能有助于为HCC患者开发新的高效抗肿瘤方法。
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