Sangineto Moris, Villani Rosanna, Cavallone Francesco, Romano Antonino, Loizzi Domenico, Serviddio Gaetano
Centro Universitario per la Ricerca e la Cura delle Epatopatie (C.U.R.E.), Liver Unit, Università di Foggia, 71100 Foggia, Italy.
Institute of Internal Medicine, Università di Foggia, 71100 Foggia, Italy.
Cancers (Basel). 2020 May 31;12(6):1419. doi: 10.3390/cancers12061419.
Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progression of HCC. The aim of this review is to elucidate the mechanisms by which lipid metabolism is involved in hepatocarcinogenesis and tumour adaptation to different conditions, focusing on the transcriptional aberrations with new insights in lipidomics and lipid zonation. This will help detect new putative therapeutic approaches in the second most frequent cause of cancer-related death.
代谢重编程在癌症的发生和发展中起着关键作用。特别是，脂质代谢已被作为肿瘤细胞的能量来源、微环境适应性和细胞信号传导进行研究。然而，脂质代谢失调在肝细胞癌（HCC）中的具体作用尚未得到广泛描述。脂肪酸合成、β-氧化和细胞脂质组成的改变有助于HCC的发生和发展。本综述的目的是阐明脂质代谢参与肝癌发生和肿瘤对不同条件适应性的机制，重点关注脂质组学和脂质分区方面新见解的转录异常。这将有助于在癌症相关死亡的第二大常见原因中发现新的潜在治疗方法。
