2003年至2015年87例犬毛发皮肤恶性黑色素瘤的术后结果及预后因素
Post-surgical outcome and prognostic factors in canine malignant melanomas of the haired skin: 87 cases (2003-2015).
作者信息
Laver Travis, Feldhaeusser Brittany R, Robat Cecilia S, Baez Jennifer L, Cronin Kim L, Buracco Paolo, Annoni Maurizio, Regan Rebecca C, McMillan Sarah K, Curran Kaitlin M, Selmic Laura E, Shiu Kai-Biu, Clark Kyle, Fagan Erin, Thamm Douglas H
机构信息
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30605, USA (Laver, Feldhaeusser); Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA (Robat); Center for Animal Referral and Emergency Services, 2010 Cabot Blvd. West, Suite D, Langhorne, Pennsylvania 19047, USA (Baez); New England Veterinary Oncology Group, Ste C, 180 Bear Hill Road, Waltham, Massachusetts 02454, USA (Cronin); Department of Veterinary Science, School of Veterinary Medicine, Universita' degli Studi di Torino, 10095 Turin, Italy (Buracco); Clinica Veterinaria Tibaldi, Viale Tibaldi, 66, 20136, Milan, Italy (Annoni); Bluepearl Georgia Veterinary Specialists, 455 Abernathy Road NE, Sandy Springs, Georgia 30328, USA (Regan); Veterinary Emergency and Referral Center of Hawaii, 1347 Kapiolani Blvd #103, Honolulu, Hawaii 96814, USA (McMillan); College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA (Curran); Department of Veterinary Medicine, Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois 61802, USA (Selmic); Veterinary Specialty Center, 1612 High Point Road, Middleton, Wisconsin 53562, USA (Shiu); Massey University, Palmerston North 4442, New Zealand (Clark); Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24060, USA (Fagan); Flint Animal Cancer Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA (Thamm).
出版信息
Can Vet J. 2018 Sep;59(9):981-987.
The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the haired skin were retrospectively reviewed for overall survival time (OST), progression-free survival time (PFS), and prognostic factors. The post-surgery median PFS and median OST were 1282 days and 1363 days, respectively. The post-surgery metastatic rate was 21.8% with a local recurrence rate of 8%. Increasing mitotic index (MI) was predictive of a significantly decreased OST and PFS on multivariable analysis [hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.02 to 1.07 and HR: 1.04, 95% CI: 1.02 to 1.06, respectively]. Increasing age was likewise predictive of a significantly decreased OST and PFS on multivariable analysis (HR: 1.39, 95% CI: 1.17 to 1.65 and HR: 1.33, 95% CI: 1.14 to 1.54, respectively). These results confirm clinical impressions that long survival times are likely in dogs diagnosed with malignant melanoma of the haired skin when treated with surgery alone.
对87只接受手术治疗的有毛皮肤皮肤恶性黑色素瘤（CMM）犬的病历进行回顾性分析，以评估总生存时间（OST）、无进展生存时间（PFS）和预后因素。术后中位PFS和中位OST分别为1282天和1363天。术后转移率为21.8%，局部复发率为8%。多变量分析显示，有丝分裂指数（MI）增加预示着OST和PFS显著降低[风险比（HR）：1.05，95%置信区间（CI）：1.02至1.07；HR：1.04，95%CI：1.02至1.06]。多变量分析同样显示，年龄增加预示着OST和PFS显著降低（HR：1.39，95%CI：1.17至1.65；HR：1.33，95%CI：1.14至1.54）。这些结果证实了临床印象，即仅接受手术治疗的被诊断为有毛皮肤恶性黑色素瘤的犬可能有较长的生存时间。
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