Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, India.
Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, Baltimore, MD, USA.
Crit Rev Biotechnol. 2019 Feb;39(1):79-98. doi: 10.1080/07388551.2018.1500997. Epub 2018 Sep 9.
Today, environmental pollution is a serious problem, and bioremediation can play an important role in cleaning contaminated sites. Remediation strategies, such as chemical and physical approaches, are not enough to mitigate pollution problems because of the continuous generation of novel recalcitrant pollutants due to anthropogenic activities. Bioremediation using microbes is an eco-friendly and socially acceptable alternative to conventional remediation approaches. Many microbes with a bioremediation potential have been isolated and characterized but, in many cases, cannot completely degrade the targeted pollutant or are ineffective in situations with mixed wastes. This review envisages advances in systems biology (SB), which enables the analysis of microbial behavior at a community level under different environmental stresses. By applying a SB approach, crucial preliminary information can be obtained for metabolic engineering (ME) of microbes for their enhanced bioremediation capabilities. This review also highlights the integrated SB and ME tools and techniques for bioremediation purposes.
如今，环境污染是一个严重的问题，而生物修复可以在清理污染场地方面发挥重要作用。由于人为活动不断产生新型难降解污染物，化学和物理等修复策略不足以缓解污染问题。利用微生物进行生物修复是对传统修复方法的一种环保且社会可接受的替代方法。已经分离和鉴定了许多具有生物修复潜力的微生物，但在许多情况下，它们不能完全降解目标污染物，或者在混合废物的情况下无效。本综述展望了系统生物学 (SB) 的进展，该技术使我们能够在不同环境压力下分析微生物群落的行为。通过应用 SB 方法，可以为微生物的代谢工程 (ME) 获得增强其生物修复能力的关键初步信息。本综述还强调了用于生物修复目的的集成 SB 和 ME 工具和技术。
