Lane Martha J, Roy Alma F, Kearney Michael T, Pucheu-Haston Cherie M
Department of Veterinary Clinical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, Louisiana.
Louisiana Animal Disease Diagnostic Laboratory, Baton Rouge, Louisiana.
Vet Med Sci. 2018 Nov;4(4):315-325. doi: 10.1002/vms3.122. Epub 2018 Sep 10.
Relatively few studies have been published describing the patterns of staphylococcal isolation and antimicrobial resistance over time in cats. The objective of this retrospective study was to determine the frequency, location, characteristics and antimicrobial resistance profiles of staphylococci isolated by the Louisiana Animal Disease Diagnostic Laboratory between the years 2001 and 2014. All feline staphylococcal isolates were classified phenotypically. Isolates corresponding to known or possibly pathogenic species (Staphylococcus intermedius group (SIG) and Staphylococcus aureus (SA)) as well as Staphylococcus epidermidis (SE) and non-speciated coagulase-negative staphylococci (CNS) were further evaluated to determine antimicrobial resistance patterns. A total of 519 staphylococci were isolated. The largest percentage of isolates was CNS, representing 39.3% of the total, while SIG, SE, SA and non-speciated coagulase positive staphylococci (CPS) represented 18.1%, 10.2%, 8.3% and 7.3%, respectively. Methicillin resistance (MR) was identified in 57.1% of SA and 20.5% of SIG. Resistance to 3 or more antimicrobial classes (multidrug resistance; MDR) was demonstrated in 54.5% of SA and 23.9% of SIG. The prevalence of MDR increased over time in both SIG and SA, while the prevalence of MR increased over time in SIG. An increase in mean antimicrobial resistance score over time was seen in SIG. This study demonstrates a high and increasing prevalence of MDR in SIG and SA, as well as increasing prevalence of MR in SIG isolated from cats.
相对较少有研究发表描述猫科动物葡萄球菌分离模式及随时间变化的抗菌药物耐药性。这项回顾性研究的目的是确定2001年至2014年间路易斯安那动物疾病诊断实验室分离出的葡萄球菌的频率、位置、特征及抗菌药物耐药性谱。所有猫科动物葡萄球菌分离株均进行表型分类。对与已知或可能致病菌种（中间葡萄球菌群（SIG）和金黄色葡萄球菌（SA））以及表皮葡萄球菌（SE）和未分类的凝固酶阴性葡萄球菌（CNS）相对应的分离株进一步评估以确定抗菌药物耐药模式。共分离出519株葡萄球菌。分离株中比例最大的是CNS，占总数的39.3%，而SIG、SE、SA和未分类的凝固酶阳性葡萄球菌（CPS）分别占18.1%、10.2%、8.3%和7.3%。在57.1%的SA和20.5%的SIG中鉴定出耐甲氧西林（MR）。54.5%的SA和23.9%的SIG表现出对3种或更多抗菌药物类别耐药（多重耐药；MDR）。SIG和SA中MDR的患病率均随时间增加，而SIG中MR的患病率随时间增加。SIG中随时间观察到平均抗菌药物耐药性评分增加。这项研究表明，从猫分离出的SIG和SA中MDR的患病率高且不断增加，以及SIG中MR的患病率不断增加。
