Department of Community Medicine, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
Institute of Public Health, Northern State Medical University, 163000 Arkhangelsk, Russia.
Int J Environ Res Public Health. 2018 Sep 1;15(9):1905. doi: 10.3390/ijerph15091905.
Russia had a high incidence of hepatitis B virus (HBV) infection before the vaccination campaigns of 1997, 2001, 2007, which targeted newborns, adolescents, and adults, respectively. The aim of our study was to assess the prevalence of serological markers of HBV infection, associated factors, and vaccination status among young adults in Arkhangelsk, Northwest Russia. In this cross-sectional, population-based study, we used a quota sampling method to recruit 1243 adults aged 18⁻39 years. Participants completed a self-administrated questionnaire and were tested for hepatitis B markers. Associations between positivity for markers and selected sociodemographic and behavioral factors were studied by logistic regression. 10.9% of our participants were positive for at least one marker of hepatitis B, 1.2% were positive for HBsAg, and 42.1% were negative for all markers. In multivariable logistic regression analyses, age 30⁻34 years; lack of self-reported vaccination; and having ≥2 sexual partners in the last 6 months were associated with positivity for markers of hepatitis B. Hepatitis B vaccination was confirmed in 46.9% of participants. Although half of our study sample was vaccinated, four in 10 were still susceptible to infection and more than one participant in 100 showed evidence of an active infection.
在分别针对新生儿、青少年和成年人的 1997 年、2001 年和 2007 年疫苗接种活动之前，俄罗斯的乙型肝炎病毒 (HBV) 感染发生率很高。我们的研究旨在评估俄罗斯西北部阿尔汉格尔斯克的年轻成年人中乙型肝炎病毒感染的血清学标志物流行率、相关因素和疫苗接种状况。在这项横断面、基于人群的研究中，我们使用配额抽样方法招募了 1243 名年龄在 18-39 岁的成年人。参与者完成了一份自我管理的问卷，并接受了乙型肝炎标志物检测。通过逻辑回归研究了标志物阳性与选定的社会人口统计学和行为因素之间的关联。我们的参与者中有 10.9%至少有一种乙型肝炎标志物阳性，1.2% HBsAg 阳性，42.1%所有标志物均为阴性。在多变量逻辑回归分析中，30-34 岁；缺乏自我报告的疫苗接种；以及在过去 6 个月内有≥2 个性伴侣与乙型肝炎标志物阳性相关。46.9%的参与者确认接种了乙型肝炎疫苗。尽管我们研究样本的一半已接种疫苗，但仍有十分之四的人易感染，每 100 人中就有一人以上显示出活动性感染的证据。
