Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom; email:
Annu Rev Microbiol. 2018 Sep 8;72:309-330. doi: 10.1146/annurev-micro-090817-062257.
2017 marks the 60th anniversary of Krebs' seminal paper on the glyoxylate shunt (and coincidentally, also the 80th anniversary of his discovery of the citric acid cycle). Sixty years on, we have witnessed substantial developments in our understanding of how flux is partitioned between the glyoxylate shunt and the oxidative decarboxylation steps of the citric acid cycle. The last decade has shown us that the beautifully elegant textbook mechanism that regulates carbon flux through the shunt in E. coli is an oversimplification of the situation in many other bacteria. The aim of this review is to assess how this new knowledge is impacting our understanding of flux control at the TCA cycle/glyoxylate shunt branch point in a wider range of genera, and to summarize recent findings implicating a role for the glyoxylate shunt in cellular functions other than metabolism.
2017 年标志着克雷布斯关于乙醛酸支路的开创性论文发表 60 周年（巧合的是，这也是他发现柠檬酸循环 80 周年）。60 年来，我们见证了人们对通量如何在乙醛酸支路和柠檬酸循环的氧化脱羧步骤之间分配的理解有了实质性的发展。过去十年的研究表明，调节大肠杆菌中碳通量通过支路的精美优雅的教科书机制是对许多其他细菌中情况的过度简化。本文旨在评估这一新知识如何影响我们对更广泛属中 TCA 循环/乙醛酸支路分支点通量控制的理解，并总结最近发现的乙醛酸支路在代谢以外的细胞功能中的作用。
