Hennigar Stephen R, McClung James P
US Army Research Institute of Environmental Medicine, Military Nutrition Division, Natick, Massachusetts.
Am J Lifestyle Med. 2016 Feb 4;10(3):170-173. doi: 10.1177/1559827616629117. eCollection 2016 May-Jun.
Nutritional immunity is a process by which a host organism sequesters trace minerals in an effort to limit pathogenicity during infection. Circulating concentrations of minerals, such as iron and zinc, decline rapidly and dramatically with the inflammation associated with infection. The decline in iron and zinc is thought to starve invading pathogens of these essential elements, limiting disease progression and severity. The mechanisms contributing to the hypoferremia and hypozincemia of inflammation and potential interventions that exploit this process for the management of infection will be discussed.
营养免疫是宿主生物体隔离微量矿物质以在感染期间限制致病性的过程。铁和锌等矿物质的循环浓度会随着与感染相关的炎症而迅速且显著下降。铁和锌的下降被认为是使入侵病原体缺乏这些必需元素，从而限制疾病进展和严重程度。本文将讨论导致炎症性低铁血症和低锌血症的机制以及利用这一过程来管理感染的潜在干预措施。
