通过规律运动和营养支持减轻衰老对骨骼肌的不良影响。
Attenuation of Adverse Effects of Aging on Skeletal Muscle by Regular Exercise and Nutritional Support.
作者信息
Leon Arthur S
机构信息
University of Minnesota, Minneapolis, Minnesota.
出版信息
Am J Lifestyle Med. 2016 Jun 23;11(1):4-16. doi: 10.1177/1559827615589319. eCollection 2017 Jan-Feb.
Abstract
Beginning early in midlife, natural/primary aging is inevitably associated with a progressive reduction in muscle mass and function. This process can progress with aging to a substantial loss of strength, particularly in the lower extremities, reducing mobility. This condition, commonly referred to as sarcopenia, can result in frailty, reducing one's ability to live independently. This article reviews the underlying biological process contributing to the development of sarcopenia and the roles of regular exercise and nutritional support for attenuating aging-associated muscle loss as well as risk and management of sarcopenia and associated frailty.
摘要
从中年早期开始，自然/原发性衰老不可避免地伴随着肌肉质量和功能的逐渐下降。随着年龄的增长，这个过程会导致力量大幅丧失，尤其是下肢力量，从而降低活动能力。这种情况通常被称为肌肉减少症，会导致身体虚弱，降低独立生活的能力。本文综述了导致肌肉减少症发生的潜在生物学过程，以及规律运动和营养支持在减轻与衰老相关的肌肉流失方面的作用，以及肌肉减少症和相关虚弱的风险与管理。
相似文献
1
Attenuation of Adverse Effects of Aging on Skeletal Muscle by Regular Exercise and Nutritional Support.通过规律运动和营养支持减轻衰老对骨骼肌的不良影响。
Am J Lifestyle Med. 2016 Jun 23;11(1):4-16. doi: 10.1177/1559827615589319. eCollection 2017 Jan-Feb.
2
Understanding Sarcopenia Development: A Role for Healthy Behaviors.了解肌肉减少症的发展：健康行为的作用。
Am J Lifestyle Med. 2017 Jan;11(1):17-20. doi: 10.1177/1559827616674163. Epub 2017 Jan 10.
3
Nutrition and Exercise in Sarcopenia.肌少症中的营养与运动
Curr Protein Pept Sci. 2018;19(7):649-667. doi: 10.2174/1389203717666161227144349.
4
Association of CT-based diagnosis of sarcopenia with prognosis and treatment response in patients at risk of malnutrition - A secondary analysis of the Effect of early nutritional support on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial (EFFORT) trial.基于 CT 的肌肉减少症诊断与营养不良风险患者的预后和治疗反应的相关性：早期营养支持对衰弱、功能结局和营养不良住院患者恢复的影响（EFFORT）试验的二次分析。
Clin Nutr. 2023 Feb;42(2):199-207. doi: 10.1016/j.clnu.2022.12.006. Epub 2022 Dec 22.
5
Nutritional strategies for maintaining muscle mass and strength from middle age to later life: A narrative review.从中年到老年维持肌肉质量和力量的营养策略：叙事性综述。
Maturitas. 2020 Feb;132:57-64. doi: 10.1016/j.maturitas.2019.11.007. Epub 2019 Nov 27.
6
Muscle tissue changes with aging.肌肉组织会随着年龄增长而发生变化。
Acta Med Port. 2013 Jan-Feb;26(1):51-5. Epub 2013 Apr 24.
7
Beyond Physical Exercise: The Role of Nutrition, Gut Microbiota and Nutraceutical Supplementation in Reducing Age-Related Sarcopenia.超越体育锻炼：营养、肠道微生物群和营养补充剂在减少与年龄相关的肌肉减少症中的作用。
Curr Aging Sci. 2021;14(2):94-104. doi: 10.2174/1874609814666210203090458.
8
Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people.肌少症的预防与优化管理：关于联合运动与营养干预以改善老年人肌肉状况的综述
Clin Interv Aging. 2015 May 11;10:859-69. doi: 10.2147/CIA.S55842. eCollection 2015.
9
Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment.肌肉减少症：当前定义、诊断与治疗概述
Curr Protein Pept Sci. 2018 May 14;19(7):633-638. doi: 10.2174/1389203718666170607113459.
10
Potential roles of vitamin E in age-related changes in skeletal muscle health.维生素 E 在与年龄相关的骨骼肌健康变化中的潜在作用。
Nutr Res. 2018 Jan;49:23-36. doi: 10.1016/j.nutres.2017.09.005. Epub 2017 Sep 21.
引用本文的文献
1
Impact of physical activity patterns and sedentary behavior on sarcopenia prevalence among adults aged 18 to 59: A cross-sectional study from NHANES.身体活动模式和久坐行为对18至59岁成年人肌肉减少症患病率的影响：一项来自美国国家健康与营养检查调查（NHANES）的横断面研究。
Medicine (Baltimore). 2025 Sep 5;104(36):e44312. doi: 10.1097/MD.0000000000044312.
2
Handgrip Strength Asymmetry in Female Basketball Players: The Critical Role of Arm Position and the Challenge of Statistical Power.女子篮球运动员握力不对称性：手臂位置的关键作用及统计功效的挑战
Sports (Basel). 2025 Aug 21;13(8):279. doi: 10.3390/sports13080279.
3
Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions.揭开胰岛素抵抗之谜：从主要机制见解、后果到治疗干预
Int J Mol Sci. 2025 Mar 19;26(6):2770. doi: 10.3390/ijms26062770.
4
Effects of Hot Water Extract and Oregonin on Muscle Loss and Muscle Atrophy in C2C12 Murine Skeletal Muscle Cells.热水提取物和 Oregonin 对 C2C12 小鼠骨骼肌细胞肌肉损失和肌肉萎缩的影响。
Pharmaceuticals (Basel). 2024 Dec 10;17(12):1661. doi: 10.3390/ph17121661.
5
Cross-sectional association of physical activity levels with risks of sarcopenia among older Taiwanese adults.台湾老年人身体活动水平与肌肉减少症风险的横断面关联。
BMC Geriatr. 2024 Jun 27;24(1):560. doi: 10.1186/s12877-024-05087-x.
6
The key values and factors identified by older adults to promote physical activity and reduce sedentary behaviour using co-production approaches: a scoping review.老年人通过共同生产方法确定的促进身体活动和减少久坐行为的关键价值观和因素：范围综述。
BMC Geriatr. 2023 Jun 16;23(1):371. doi: 10.1186/s12877-023-04005-x.
7
Influencing factors of weak grip strength and fall: a study based on the China Health and Retirement Longitudinal Study (CHARLS).握力弱和跌倒的影响因素：基于中国健康与养老追踪调查（CHARLS）的研究。
BMC Public Health. 2022 Dec 13;22(1):2337. doi: 10.1186/s12889-022-14753-x.
8
Energy Metabolism Changes and Dysregulated Lipid Metabolism in Postmenopausal Women.绝经后女性的能量代谢变化和脂质代谢失调。
Nutrients. 2021 Dec 20;13(12):4556. doi: 10.3390/nu13124556.
9
A cross-sectional study about the relationship between physical activity and sarcopenia in Taiwanese older adults.一项关于台湾老年人身体活动与肌肉减少症之间关系的横断面研究。
Sci Rep. 2021 Jun 1;11(1):11488. doi: 10.1038/s41598-021-90869-1.
10
Association Between Parental Socioeconomic Status and Skeletal Muscle Mass in Chinese College Students: Fitness Improvement Tactics in Youths (FITYou) Project.中国大学生父母社会经济地位与骨骼肌质量的关联：青少年健身改善策略（FITYou）项目
Risk Manag Healthc Policy. 2020 Nov 4;13:2457-2467. doi: 10.2147/RMHP.S266891. eCollection 2020.
本文引用的文献
1
Role of PGC-1α in sarcopenia: etiology and potential intervention - a mini-review.PGC-1α在肌肉减少症中的作用：病因及潜在干预——一篇综述短文
Gerontology. 2015;61(2):139-48. doi: 10.1159/000365947. Epub 2014 Dec 6.
2
Modification of insulin sensitivity and glycemic control by activity and exercise.运动和锻炼对胰岛素敏感性和血糖控制的影响。
Med Sci Sports Exerc. 2013 Oct;45(10):1868-77. doi: 10.1249/MSS.0b013e318295cdbb.
3
Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle.运动与营养干预以改善衰老骨骼肌中的蛋白质合成障碍。
Exerc Sport Sci Rev. 2013 Oct;41(4):216-23. doi: 10.1097/JES.0b013e3182a4e699.
4
Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance.自噬对于运动训练引起的骨骼肌适应和提高身体机能是必需的。
FASEB J. 2013 Oct;27(10):4184-93. doi: 10.1096/fj.13-228486. Epub 2013 Jun 27.
5
Vitamin D for health: a global perspective.维生素 D 与健康：全球视角。
Mayo Clin Proc. 2013 Jul;88(7):720-55. doi: 10.1016/j.mayocp.2013.05.011. Epub 2013 Jun 18.
6
Anabolic resistance of muscle protein synthesis with aging.肌肉蛋白质合成的合成代谢抵抗与衰老。
Exerc Sport Sci Rev. 2013 Jul;41(3):169-73. doi: 10.1097/JES.0b013e318292f3d5.
7
Effect of exercise on the skeletal muscle proteome in patients with type 2 diabetes.运动对 2 型糖尿病患者骨骼肌蛋白质组的影响。
Med Sci Sports Exerc. 2013 Jun;45(6):1069-76. doi: 10.1249/MSS.0b013e3182814917.
8
Effects of vitamin d on muscle function and performance: a review of evidence from randomized controlled trials.维生素 D 对肌肉功能和表现的影响：来自随机对照试验的证据综述。
Ther Adv Chronic Dis. 2011 Jan;2(1):25-37. doi: 10.1177/2040622310381934.
9
The roles of vitamin D in skeletal muscle: form, function, and metabolism.维生素 D 在骨骼肌中的作用：形态、功能和代谢。
Endocr Rev. 2013 Feb;34(1):33-83. doi: 10.1210/er.2012-1012. Epub 2012 Nov 20.
10
Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis.蛋白质补充剂增强骨骼肌对抗阻型运动训练的适应反应：一项荟萃分析。
Am J Clin Nutr. 2012 Dec;96(6):1454-64. doi: 10.3945/ajcn.112.037556. Epub 2012 Nov 7.
Zotero 插件