Department of Physiological Sciences, Piracicaba Dentistry School, University of Campinas, 13414-903 Piracicaba, SP, Brazil.
Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903, Araraquara, SP, Brazil.
Microb Pathog. 2018 Dec;125:116-121. doi: 10.1016/j.micpath.2018.09.014. Epub 2018 Sep 8.
Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan. The difficulty in identification, incorrect use of antifungal drugs, and treatment failure are causes of high mortality. Since then, C. auris has been increasingly reported from East Asia to North America, with substantial fatalities and misidentification. This review aims at describing the epidemiology, virulence, risk factors, resistance, and therapeutic options in C. auris infections.
耳念珠菌作为一种对多种抗真菌药物具有耐药性的病原体出现，并与医院环境中个体之间具有高传播能力的爆发性感染有关。耳念珠菌于 2009 年首次在日本的一位患者的外耳耳道分泌物中被分离出来后被描述。鉴定困难、抗真菌药物使用不当以及治疗失败是导致高死亡率的原因。自那时以来，耳念珠菌已从东亚逐渐传播到北美，导致大量死亡和误诊。本综述旨在描述耳念珠菌感染的流行病学、毒力、危险因素、耐药性和治疗选择。
