School of Medicine, Menzies Health Institute Queensland, Griffith University, 68 University Drive, Meadowbrook, QLD 4131, Australia.
Faculty of Health, University of Canberra, University Drive, Bruce, ACT 2617, Australia.
Nutrients. 2018 Sep 7;10(9):1264. doi: 10.3390/nu10091264.
Dietary flavonoid intakes can influence gut microbiota (GM), which in turn can affect immune function and host metabolism, both vital considerations in cystic fibrosis (CF) management. In CF, GM may be altered and link to CF respiratory events. This study explored the relationship between flavonoid intakes and GM in free-living adults with CF. Associations between the overall GM variations (unweighted and weighted UniFrac distances between pyrosequencing results of bacterial 16-ss rDNA from frozen faecal samples of sixteen CF adults) and standardised dietary flavonoid intakes (a validated flavonoid-specific food frequency questionnaire) were analysed using adonis tests. Flavonoid intakes that were significant at a false discovery rate (FDR) < 0.3 were subjected to Spearman correlation tests with standardised bacterial relative abundances (FDR < 0.3). Gallocatechin intakes ( = 0.047, = 0.285) were associated with unweighted UniFrac distances. Intakes of apigenin ( = 0.028, = 0.227) and kaempferol ( = 0.029, = 0.227), and % flavonoid intake as flavones ( = 0.013, = 0.227) and flavonols ( = 0.016, = 0.227) (both excluding contribution of tea) were associated with weighted UniFrac distances. Among these, gallocatechin correlated with the genus and family (). Gallocatechin correlated negatively with class (). Intakes of some flavonoids may be associated with GM variations with potential consequences for metabolism, immune function, and inflammation, which are important in CF lung disease and co-morbidity management.
饮食类黄酮的摄入量可以影响肠道微生物群（GM），而 GM 反过来又可以影响免疫功能和宿主代谢，这在囊性纤维化（CF）的管理中都是至关重要的考虑因素。在 CF 中，GM 可能会发生改变，并与 CF 呼吸道事件有关。本研究旨在探索 CF 成人中类黄酮摄入量与 GM 之间的关系。使用 adonis 检验分析了总体 GM 变化（通过对 16 名 CF 成人冷冻粪便样本的细菌 16-ss rDNA 进行焦磷酸测序结果的未加权和加权 UniFrac 距离）与标准化饮食类黄酮摄入量（经过验证的类黄酮特异性食物频率问卷）之间的相关性。在错误发现率（FDR）<0.3 时，将显著的类黄酮摄入量进行 Spearman 相关性检验，与标准化细菌相对丰度（FDR<0.3）。表儿茶素摄入量（ = 0.047， = 0.285）与未加权 UniFrac 距离相关。芹菜素（ = 0.028， = 0.227）和山柰酚（ = 0.029， = 0.227）的摄入量，以及类黄酮摄入量作为黄酮类（ = 0.013， = 0.227）和黄酮醇（ = 0.016， = 0.227）（均排除茶的贡献）与加权 UniFrac 距离相关。在这些类黄酮中，表儿茶素与属和科呈负相关（）。表儿茶素与纲（）呈负相关。一些类黄酮的摄入量可能与 GM 变化有关，这可能对代谢、免疫功能和炎症产生影响，这些在 CF 肺部疾病和合并症的管理中很重要。
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