Meka Ijeoma A, Anyim Obumneme B, Enebe Joseph T, Ukwaja Kingsley N, Ugonabo Martin C
Department of Chemical Pathology, University of Nigeria Enugu Campus, Enugu, Nigeria.
Department of Internal Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Enugu, Nigeria.
Open Med (Wars). 2018 Sep 8;13:350-358. doi: 10.1515/med-2018-0053. eCollection 2018.
Dyslipidaemia and hypertension are established major risk factors for cardiovascular diseases. The suggested roles of miRNA-122 and ADAM17 in lipid metabolism can therefore be applied in the management of metabolic disorders. The authors' aim was to determine the association between miRNA-122 and ADAM17, as well as the association between miRNA-122 and lipid fractions, in the study participants.
A comparative cross-sectional study was conducted among 200 hypertensive patients and 100 non-hypertensive adult controls between May, 2015, and June, 2016, in Nigeria. Lipids were analysed with spectrophotometric methods whereas ADAM17 and miRNA-122 were analysed with enzyme linked immunosorbent assay and quantitative polymerase chain reaction, respectively.
The mean (standard deviation [SD]) ages of 200 hypertensives and 100 controls were 56.3 (6.9) and 54.9 (8.3) years, respectively. miRNA-112 and ADAM17 had significantly higher values among dyslipidaemic individuvals compared with non-dyslipidaemic participants. The correlation between miRNA-122 and ADAM17 levels was strongly positive, r=0.82, p<0.05. LDL-cholesterol and total cholesterol also showed statistically significant positive correlation with miRNA-122, r=0.53, r=0.51, (p< 0.001) respectively.
In this study, miRNA-122 showed a strong correlation with ADAM17 and a positive correlation with LDL-cholesterol and total cholesterol. These findings support the stimulant roles of miRNA-122 and ADAM17 in lipid metabolism and thus could be used in the management of dyslipidaemia.
血脂异常和高血压是公认的心血管疾病主要危险因素。因此，miRNA - 122和ADAM17在脂质代谢中所提示的作用可应用于代谢紊乱的管理。作者的目的是确定研究参与者中miRNA - 122与ADAM17之间的关联，以及miRNA - 122与血脂成分之间的关联。
2015年5月至2016年6月在尼日利亚对200例高血压患者和100例非高血压成年对照者进行了一项比较横断面研究。采用分光光度法分析血脂，而分别采用酶联免疫吸附测定法和定量聚合酶链反应分析ADAM17和miRNA - 122。
200例高血压患者和100例对照者的平均（标准差[SD]）年龄分别为56.3（6.9）岁和54.9（8.3）岁。与非血脂异常参与者相比，血脂异常个体的miRNA - 112和ADAM17值显著更高。miRNA - 122与ADAM17水平之间的相关性呈强正相关，r = 0.82，p < 0.05。低密度脂蛋白胆固醇和总胆固醇与miRNA - 122也显示出统计学上显著的正相关，分别为r = 0.53，r = 0.51，（p < 0.001）。
在本研究中，miRNA - 122与ADAM17呈强相关，与低密度脂蛋白胆固醇和总胆固醇呈正相关。这些发现支持了miRNA - 122和ADAM17在脂质代谢中的促进作用，因此可用于血脂异常的管理。
