孕酮是否会调节突触传递？

Is synaptic transmission modulated by progesterone?

作者信息

Meiri H

出版信息

Brain Res. 1986 Oct 15;385(1):193-6. doi: 10.1016/0006-8993(86)91566-0.

Abstract

The influence of the gonadosteroid hormone progesterone on synaptic transmission was studied using the frog neuromuscular preparation. Intracellular recording of synaptic potentials revealed enhanced release of acetylcholine from motor nerve terminals exposed to progesterone (3 nM-3 mM). The following effects were observed. An augmented quantal content of evoked release of transmitter; an elevation in synaptic facilitation; and a substantial increase in the rate of spontaneously occurring miniature endplate potentials. It is suggested that synaptic transmission at the neuromuscular junction may be naturally modulated by the physiologically oscillating level of progesterone.

摘要

利用青蛙神经肌肉标本研究了性腺甾体激素孕酮对突触传递的影响。通过细胞内记录突触电位发现，暴露于孕酮（3 nM - 3 mM）的运动神经末梢释放的乙酰胆碱增加。观察到以下效应：递质诱发释放的量子含量增加；突触易化增强；自发出现的微小终板电位频率大幅增加。研究表明，神经肌肉接头处的突触传递可能受到孕酮生理振荡水平的自然调节。