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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Br J Pharmacol. 1973 Apr;47(4):819-26. doi: 10.1111/j.1476-5381.1973.tb08209.x.

The potencies of four series of N-alkyl-1,2,3-benzotriazinium iodides have been estimated on the frog rectus abdominis and chick biventer cervicis preparations.2. The partition coefficients between chloroform and water were measured for all of the compounds, as well as the ionization constants for some members of two of the series.3. The potencies of the compounds increased with the number of carbon atoms in the N-alkyl side chain up to a maximum at the n-butyl homologue while partition coefficients increased up to the n-pentyl homologue, and there may be some association between the lipid solubilities of the compounds and their biological activity.4. The responses of the tissues to the benzotriaziniums were not abolished by tubocurarine, indicating that the site of action was not at acetylcholine receptors.5. The similarity between the actions of the benzotriaziniums and those of quinine and quinidine is discussed.

已在青蛙腹直肌和鸡颈二腹肌标本上评估了四个系列的N-烷基-1,2,3-苯并三嗪碘化物的效能。
测定了所有化合物在氯仿和水之间的分配系数，以及其中两个系列中一些成员的电离常数。
化合物的效能随着N-烷基侧链中碳原子数的增加而增加，直至正丁基同系物达到最大值，而分配系数直至正戊基同系物时增加，并且化合物的脂溶性与其生物活性之间可能存在某种关联。
筒箭毒碱并未消除组织对苯并三嗪的反应，这表明作用部位不在乙酰胆碱受体。
讨论了苯并三嗪与奎宁和奎尼丁作用之间的相似性。

Br J Pharmacol. 1973 Apr;47(4):819-26. doi: 10.1111/j.1476-5381.1973.tb08209.x.

The potencies of four series of N-alkyl-1,2,3-benzotriazinium iodides have been estimated on the frog rectus abdominis and chick biventer cervicis preparations.2. The partition coefficients between chloroform and water were measured for all of the compounds, as well as the ionization constants for some members of two of the series.3. The potencies of the compounds increased with the number of carbon atoms in the N-alkyl side chain up to a maximum at the n-butyl homologue while partition coefficients increased up to the n-pentyl homologue, and there may be some association between the lipid solubilities of the compounds and their biological activity.4. The responses of the tissues to the benzotriaziniums were not abolished by tubocurarine, indicating that the site of action was not at acetylcholine receptors.5. The similarity between the actions of the benzotriaziniums and those of quinine and quinidine is discussed.

已在青蛙腹直肌和鸡颈二腹肌标本上评估了四个系列的N-烷基-1,2,3-苯并三嗪碘化物的效能。
测定了所有化合物在氯仿和水之间的分配系数，以及其中两个系列中一些成员的电离常数。
化合物的效能随着N-烷基侧链中碳原子数的增加而增加，直至正丁基同系物达到最大值，而分配系数直至正戊基同系物时增加，并且化合物的脂溶性与其生物活性之间可能存在某种关联。
筒箭毒碱并未消除组织对苯并三嗪的反应，这表明作用部位不在乙酰胆碱受体。
讨论了苯并三嗪与奎宁和奎尼丁作用之间的相似性。