Division of Endocrinology, Ann and Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
J Pediatr. 2018 Dec;203:144-149.e1. doi: 10.1016/j.jpeds.2018.07.056. Epub 2018 Sep 10.
To evaluate the association between cord blood amino acid and acylcarnitine profiles and measures of adiposity and hyperinsulinemia in healthy newborns.
A cross-sectional study of 118 full-term infants born to mothers without gestational diabetes was performed. Cord blood leptin, C-peptide, acylcarnitine, and amino acid levels were measured. Body composition was measured by air displacement plethysmography. Multivariate linear regression and principal component analysis were used to analyze associations of cord blood metabolites with newborn anthropometrics, leptin, and C-peptide.
Acylcarnitines AC C2, AC C4-DC/Ci4-DC, and AC C8:1-OH/C6:1-DC were positively associated with leptin, and AC C14, AC C14:2, AC C16, AC C18, and AC C18:2 were negatively associated with C-peptide (P ≤ .0016). Principal component analysis revealed a positive association between factor 1(AC C2, AC C3, AC C5, AC C4/Ci4, AC C4-OH, AC C4-DC/Ci4-DC, glutamate/glutamine, and glycine) and adiposity measures.
The positive association of AC C2 and AC C4-DC/Ci4-DC levels with leptin may reflect excess fat stores, higher fatty acid oxidation rate, and mitochondrial dysfunction leading to accumulation of acylcarnitine intermediates. Principal component analysis revealed a positive association between branched chain amino acid and ketone body metabolites and adiposity, confirming prior findings in adults. Cord blood acylcarnitine profiles may identify at-risk children before obesity or insulin resistance develops.
评估健康新生儿脐带血氨基酸和酰基肉碱谱与肥胖和高胰岛素血症指标之间的关系。
对 118 例无妊娠糖尿病母亲分娩的足月婴儿进行横断面研究。检测脐带血瘦素、C 肽、酰基肉碱和氨基酸水平。采用空气置换体描记法测量身体成分。采用多元线性回归和主成分分析来分析脐带血代谢物与新生儿人体测量学、瘦素和 C 肽的相关性。
酰基肉碱 AC C2、AC C4-DC/Ci4-DC 和 AC C8:1-OH/C6:1-DC 与瘦素呈正相关，而 AC C14、AC C14:2、AC C16、AC C18 和 AC C18:2 与 C 肽呈负相关（P≤0.0016）。主成分分析显示，因子 1（AC C2、AC C3、AC C5、AC C4/Ci4、AC C4-OH、AC C4-DC/Ci4-DC、谷氨酸/谷氨酰胺和甘氨酸）与肥胖指标呈正相关。
AC C2 和 AC C4-DC/Ci4-DC 水平与瘦素呈正相关，可能反映了脂肪储存过多、脂肪酸氧化率升高和线粒体功能障碍导致酰基肉碱中间产物的积累。主成分分析显示支链氨基酸和酮体代谢物与肥胖呈正相关，证实了成年人的先前发现。脐带血酰基肉碱谱可能在肥胖或胰岛素抵抗发生之前识别高危儿童。
