Arain Abeer, Matthiesen Chance
Department of Internal Medicine, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Department of Internal Medicine, University of Illinois Urbana-Champaign, Champaign, IL, USA.
Hematol Oncol Stem Cell Ther. 2019 Sep;12(3):133-139. doi: 10.1016/j.hemonc.2018.08.001. Epub 2018 Sep 8.
Vitamins are the organic compounds that have long been known to play a significant role in our body by functioning as hormones and antioxidants. Vitamin D, a fat-soluble vitamin, is the main regulator of calcium hemostasis in our body. At the same time, it is also known to show its potential effects on the immune system by modulating the differentiation, activation, and proliferation of T and B lymphocytes. The immunomodulatory properties of vitamin D are also known to have a crucial role in the prevention and treatment of graft-versus-host disease. Patients undergoing hematopoietic stem cell transplantation are particularly at risk of vitamin D deficiency. This review article expands our understanding of vitamin D, its immunomodulatory effects, and its role in prevention and treatment of graft-versus-host disease.
维生素是一类有机化合物，长期以来人们已知其作为激素和抗氧化剂在我们体内发挥着重要作用。维生素D是一种脂溶性维生素，是我们体内钙稳态的主要调节因子。同时，人们还知道它通过调节T和B淋巴细胞的分化、激活和增殖对免疫系统发挥潜在作用。维生素D的免疫调节特性在移植物抗宿主病的预防和治疗中也起着关键作用。接受造血干细胞移植的患者尤其有维生素D缺乏的风险。这篇综述文章扩展了我们对维生素D、其免疫调节作用以及它在移植物抗宿主病预防和治疗中的作用的理解。
