Merchant S H, Haubenberger D, Hallett M
Department of Neurology, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Clin Neurophysiol Pract. 2018 May 15;3:107-113. doi: 10.1016/j.cnp.2018.05.001. eCollection 2018.
Functional tremors can be diagnosed based on clinical and physiologic criteria such as entrainment, suggestibility, distractibility, variable nature with the associated clinical history of psychosomatic co-morbidities. The current case report highlights the underrecognized utility of neurophysiology in the correct diagnosis of tremors, providing useful clinical and neurophysiologic insights into clinical and physiological assessment of tremors.
A 62-year-old woman with a past medical history of polio was referred by a movement disorders neurologist for evaluation of tremor with concerns of a likely functional etiology. On first assessment there were findings notable for a possible organic etiology, but upon subsequent evaluation the tremor was noted to be variable and entrainable, suggestive of a functional etiology. Neurophysiological tremor study could identify an underlying organic tremor (likely of multi-factorial etiology). Tremor entrainment with contralateral hand tapping could be mirror movements or functional movements, as the underlying organic tremor was not entrained. The amplitude of mirrored movement was commensurate with the tapping amplitude.
Functional tremors may mask an underlying organic tremor. Additionally, motor overflow which may happen especially with large amplitude movements may masquerade as mirror movements, which can be difficult to differentiate from an entrained functional tremor. Objective physiology and refinement of the current clinical and physiologic tremor evaluation techniques may help identify an underlying organic etiology.
功能性震颤可根据临床和生理标准进行诊断,如诱发性、暗示性、分散性、性质多变以及伴有身心共病的临床病史。本病例报告强调了神经生理学在震颤正确诊断中未被充分认识的作用,为震颤的临床和生理评估提供了有用的临床和神经生理学见解。
一名62岁有小儿麻痹症病史的女性被运动障碍神经科医生转诊,以评估震颤,怀疑可能是功能性病因。初次评估时有一些可能提示器质性病因的发现,但在随后的评估中,发现震颤是可变的且可被诱发,提示为功能性病因。神经生理学震颤研究可识别出潜在的器质性震颤(可能是多因素病因)。用对侧手轻敲诱发震颤时,可能出现镜像运动或功能性运动,因为潜在的器质性震颤未被诱发。镜像运动的幅度与轻敲幅度相当。
功能性震颤可能掩盖潜在的器质性震颤。此外,尤其是大幅度运动时可能发生的运动溢出可能伪装成镜像运动,这可能难以与被诱发的功能性震颤区分开来。客观生理学以及当前临床和生理震颤评估技术的完善可能有助于识别潜在的器质性病因。