Centre de Recherches sur la Cognition Animale (CRCA), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, Toulouse, France.
Center for Integrative Biology, Facultad de Ciencias, Universidad Mayor, Santiago, Chile.
Neurotox Res. 2019 Aug;36(2):257-267. doi: 10.1007/s12640-018-9942-y. Epub 2018 Sep 13.
Generation of new neurons is a tightly regulated process that involves several intrinsic and extrinsic factors. Among them, a metabolic switch from glycolysis to oxidative phosphorylation, together with mitochondrial remodeling, has emerged as crucial actors of neurogenesis. However, although accumulating data raise the importance of mitochondrial morphology and function in neural stem cell proliferation and differentiation during development, information regarding the contribution of mitochondria to adult neurogenesis processes remains limited. In the present review, we discuss recent evidence covering the importance of mitochondrial morphology, function, and energy metabolism in the regulation of neuronal development and adult neurogenesis, and their impact on memory processes.
神经元的产生是一个受到严格调控的过程，涉及多种内在和外在因素。其中，从糖酵解到氧化磷酸化的代谢转换，以及线粒体重塑，已成为神经发生的关键因素。然而，尽管越来越多的数据表明线粒体形态和功能在发育过程中神经干细胞的增殖和分化中具有重要作用，但有关线粒体对成年神经发生过程的贡献的信息仍然有限。在本综述中，我们讨论了最近的证据，这些证据涵盖了线粒体形态、功能和能量代谢在调节神经元发育和成年神经发生中的重要性，以及它们对记忆过程的影响。
