线粒体动力学在调节癌症和干细胞独特表型中的作用
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.
作者信息
Chen Hsiuchen, Chan David C
机构信息
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA.
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA.
出版信息
Cell Metab. 2017 Jul 5;26(1):39-48. doi: 10.1016/j.cmet.2017.05.016. Epub 2017 Jun 22.
Abstract
Cancer and stem cells appear to share a common metabolic profile that is characterized by high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients, this metabolic strategy provides sufficient cellular ATP while additionally providing important metabolites necessary for the biosynthetic demands of continuous cell proliferation. Recent studies indicate that this metabolic profile is dependent on genes that regulate the fusion and fission of mitochondria. High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling.
摘要
癌症细胞和干细胞似乎具有共同的代谢特征，其特点是通过有氧糖酵解对葡萄糖的高利用率。在营养充足的情况下，这种代谢策略能提供足够的细胞三磷酸腺苷（ATP），同时还能提供持续细胞增殖的生物合成需求所需的重要代谢物。最近的研究表明，这种代谢特征依赖于调节线粒体融合和裂变的基因。高水平的线粒体裂变活动与某些癌细胞的高增殖和侵袭性相关，也与某些干细胞的自我更新和抗分化能力相关。这些观察结果揭示了线粒体通过影响代谢和细胞信号传导来调节细胞生理的新方式。
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