Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan, China.
Translational Medicine Research, China Medical University Hospital, Taichung, Taiwan, China.
Curr Med Chem. 2020;27(10):1634-1646. doi: 10.2174/0929867325666180914104633.
Treatment of cardiovascular disease has achieved great success using artificial implants, particularly synthetic-polymer made grafts. However, thrombus formation and restenosis are the current clinical problems need to be conquered. New biomaterials, modifying the surface of synthetic vascular grafts, have been created to improve long-term patency for the better hemocompatibility. The vascular biomaterials can be fabricated from synthetic or natural polymers for vascular tissue engineering. Stem cells can be seeded by different techniques into tissue-engineered vascular grafts in vitro and implanted in vivo to repair the vascular tissues. To overcome the thrombogenesis and promote the endothelialization effect, vascular biomaterials employing nanotopography are more bio-mimic to the native tissue made and have been engineered by various approaches such as prepared as a simple surface coating on the vascular biomaterials. It has now become an important and interesting field to find novel approaches to better endothelization of vascular biomaterials. In this article, we focus to review the techniques with better potential improving endothelization and summarize for vascular biomaterial application. This review article will enable the development of biomaterials with a high degree of originality, innovative research on novel techniques for surface fabrication for vascular biomaterials application.
心血管疾病的治疗已经在人工植入物方面取得了巨大的成功，特别是合成聚合物制成的移植物。然而，血栓形成和再狭窄是目前需要克服的临床问题。为了改善长期通畅性和更好的血液相容性，已经开发出了新的生物材料来修饰合成血管移植物的表面。血管生物材料可以由合成或天然聚合物制成，用于血管组织工程。干细胞可以通过不同的技术在体外接种到组织工程化的血管移植物中，并在体内植入以修复血管组织。为了克服血栓形成并促进内皮化作用，采用纳米形貌的血管生物材料更能模拟天然组织，并通过各种方法进行工程化，例如在血管生物材料上制备简单的表面涂层。寻找更好的血管生物材料内皮化的新方法已成为一个重要而有趣的领域。本文重点综述了具有更好内皮化潜力的技术，并对血管生物材料的应用进行了总结。这篇综述文章将促进具有高度原创性的生物材料的发展，为血管生物材料应用的表面制造新技术进行创新性研究。
