Jung Yongsik, Gho Sung-Min, Back Seung Nam, Ha Taeyang, Kang Doo Kyoung, Kim Tae Hee
1Department of Surgery, Ajou University School of Medicine, Suwon, South Korea.
MR Clinical Research and Development GE Healthcare, Gangnam, Republic of Korea.
Br J Radiol. 2019 Jan;92(1093):20180479. doi: 10.1259/bjr.20180479. Epub 2018 Sep 21.
To compare the relaxation times acquired with synthetic MRI to those of multi-echo spin-echo sequences and to evaluate the usefulness of synthetic MRI in the clinical setting.
From January 2017 to May 2017, we included 51 patients with newly diagnosed breast cancer, who underwent additional synthetic MRI and multiecho spin echo (MESE) mapping sequences. Synthetic MRI technique uses a multiecho and multidelay acquisition method for the simultaneous quantification of physical properties such as and relaxation times and proton density image map. A radiologist with 9 years of experience in breast imaging drew region of interests manually along the tumor margins on two consecutive axial sections including the center of tumor mass and in the fat tissue of contralateral breast on both synthetic map and MESE map images.
The mean relaxation time of the cancer was 84.75 ms (± 15.54) by synthetic MRI and 90.35 ms (± 19.22) by MESE mapping. The mean relaxation time of the fat was 129.22 ms (± 9.53) and 102.11 ms (± 13.9), respectively. Bland-Altman analysis showed mean difference of 8.4 ms for the breast cancer and a larger mean difference of 27.8 ms for the fat tissue. Spearman's correlation test showed that there was significant positive correlation between synthetic MRI and MESE sequences for the cancer ( = 0.713, < 0.001) and for the fat ( = 0.551, < 0.001). The positive estrogen receptor and low histologic grade were associated with little differences between two methods ( = 0.02 and = 0.043, respectively).
relaxation times of breast cancer acquired with synthetic MRI showed positive correlation with those of MESE mapping. Synthetic MRI could be useful for the evaluation of tissue characteristics by simultaneous acquisition of several quantitative physical properties.
Synthetic MRI is useful for the evaluation of relaxation times of the breast cancers.
比较通过合成磁共振成像（MRI）获得的弛豫时间与多回波自旋回波序列的弛豫时间，并评估合成MRI在临床环境中的实用性。
2017年1月至2017年5月，我们纳入了51例新诊断的乳腺癌患者，这些患者接受了额外的合成MRI和多回波自旋回波（MESE）成像序列检查。合成MRI技术采用多回波和多延迟采集方法，用于同时定量诸如T1和T2弛豫时间以及质子密度图像图谱等物理特性。一位具有9年乳腺成像经验的放射科医生在合成图像和MESE图像的连续两个轴向切片上，沿着肿瘤边缘手动绘制感兴趣区域，包括肿瘤中心以及对侧乳腺的脂肪组织。
通过合成MRI测得的癌组织平均T1弛豫时间为84.75毫秒（±15.54），通过MESE成像测得为90.35毫秒（±19.22）。脂肪组织的平均T1弛豫时间分别为129.22毫秒（±9.53）和102.11毫秒（±13.9）。Bland-Altman分析显示，乳腺癌的平均差异为8.4毫秒，脂肪组织的平均差异更大，为27.8毫秒。Spearman相关性检验表明，合成MRI与MESE序列在癌组织方面存在显著正相关（r = 0.713，P < 0.001），在脂肪组织方面也存在显著正相关（r = 0.551，P < 0.001）。雌激素受体阳性和组织学分级低与两种方法之间的差异较小相关（分别为P = 0.02和P = 0.043）。
通过合成MRI获得的乳腺癌T1弛豫时间与MESE成像的T1弛豫时间呈正相关。合成MRI通过同时采集多种定量物理特性，可能有助于评估组织特征。
合成MRI对评估乳腺癌的T1弛豫时间有用。
