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猿猴病毒40小t抗原在猴和小鼠细胞核与细胞质中的定位。

Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells.

作者信息

Ellman M, Bikel I, Figge J, Roberts T, Schlossman R, Livingston D M

出版信息

J Virol. 1984 May;50(2):623-8. doi: 10.1128/JVI.50.2.623-628.1984.

DOI:10.1128/JVI.50.2.623-628.1984
PMID:6323762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255688/
Abstract

Monkey and mouse cells producing simian virus 40 small t antigen in the absence of clearly detectable intact or truncated large T antigens were subjected to indirect immunofluorescence and biochemical cell compartment analyses. Results revealed specific immunofluorescence and small t polypeptide in both the nucleus and cytoplasm of these cells.

摘要

在没有明显可检测到的完整或截短的大T抗原的情况下产生猿猴病毒40小t抗原的猴细胞和鼠细胞,接受了间接免疫荧光和生化细胞区室分析。结果显示这些细胞的细胞核和细胞质中均有特异性免疫荧光和小t多肽。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/b14f6f2ade5e/jvirol00134-0349-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/41eab292a71b/jvirol00134-0348-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/9c417655fa94/jvirol00134-0346-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/ba00fba6abaa/jvirol00134-0346-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/6a5d55a84d7b/jvirol00134-0349-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/b14f6f2ade5e/jvirol00134-0349-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/41eab292a71b/jvirol00134-0348-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/9c417655fa94/jvirol00134-0346-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/ba00fba6abaa/jvirol00134-0346-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/6a5d55a84d7b/jvirol00134-0349-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db66/255688/b14f6f2ade5e/jvirol00134-0349-b.jpg

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Localization of the simian virus 40 small t antigen in the nucleus and cytoplasm of monkey and mouse cells.猿猴病毒40小t抗原在猴和小鼠细胞核与细胞质中的定位。
J Virol. 1984 May;50(2):623-8. doi: 10.1128/JVI.50.2.623-628.1984.
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本文引用的文献

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Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.筛选表达编码黄嘌呤 - 鸟嘌呤磷酸核糖转移酶的大肠杆菌基因的动物细胞。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2072-6. doi: 10.1073/pnas.78.4.2072.
2
Purification of biologically active simian virus 40 small tumor antigen.生物活性猿猴病毒40小肿瘤抗原的纯化
Proc Natl Acad Sci U S A. 1983 Feb;80(4):906-10. doi: 10.1073/pnas.80.4.906.
3
Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.
猿猴病毒40小肿瘤抗原可诱导肾上皮细胞中肌动蛋白细胞骨架和紧密连接的失调。
J Virol. 2003 Mar;77(5):2807-18. doi: 10.1128/jvi.77.5.2807-2818.2003.
4
Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.猿猴病毒40小t抗原刺激允许性猴细胞中的病毒DNA复制。
J Virol. 1994 May;68(5):3138-44. doi: 10.1128/JVI.68.5.3138-3144.1994.
5
Transrepression of RNA polymerase II promoters by the simian virus 40 small t antigen.猿猴病毒40小t抗原对RNA聚合酶II启动子的反式抑制作用。
J Virol. 1994 Oct;68(10):6180-7. doi: 10.1128/JVI.68.10.6180-6187.1994.
6
The t-unique coding domain is important to the transformation maintenance function of the simian virus 40 small t antigen.t独特编码结构域对猿猴病毒40小t抗原的转化维持功能很重要。
Mol Cell Biol. 1986 Apr;6(4):1172-8. doi: 10.1128/mcb.6.4.1172-1178.1986.
7
Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.多瘤病毒小T抗原增强病毒基因组在3T6小鼠成纤维细胞中的复制。
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Cellular proteins which can specifically associate with simian virus 40 small t antigen.能够与猿猴病毒40小t抗原特异性结合的细胞蛋白。
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10
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J Virol. 1989 Jul;63(7):3128-34. doi: 10.1128/JVI.63.7.3128-3134.1989.
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Cellular proteins associated with simian virus 40 early gene products in newly infected cells.新感染细胞中与猿猴病毒40早期基因产物相关的细胞蛋白质。
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