Jeon Sohee, Jung Byungju, Lee Won Ki
Ophthalmic Surg Lasers Imaging Retina. 2018 Sep 1;49(9):656-663. doi: 10.3928/23258160-20180831-02.
To evaluate the retinal morphologic characteristics of patients with macropsia caused by epiretinal membrane (ERM) based on spectral-domain optical coherence tomography (SD-OCT).
A cross-sectional, non-interventional study was performed to compare the characteristics of retinal structures in eyes with ERM according to the presence or absence of macropsia. Twenty-six patients with ERM and macropsia were defined as the macropsia group and 26 age-matched patients with ERM without macropsia were the control group. All participants underwent a full ophthalmologic examination and SD-OCT examination. Macropsia was diagnosed and quantified using a double dot chart. The thickness of retinal layers, including the outer nuclear layer (ONL) and inner segment / outer segment / retinal pigment epithelium (IS/OS/RPE) at the central fovea, were measured by electronic calipers of the SD-OCT system. The interocular ratio of each parameter was calculated for each patient and compared between the two groups. The integrity of the external limiting membrane (ELM), IS/OS junction, and cone outer segment tips (COST) line were evaluated.
The thickness of the IS/OS/RPE differed significantly between both eyes in the macropsia group (P < .001), whereas the control group was not significantly different (P = .161). The ONL in the diseased eye was significantly thicker in the macropsia group than in the control group (P = .020), whereas these two groups did not differ significantly in the thickness of ONL in the control eye (P = .860). More patients had a disrupted COST line in the macropsia group (P < .001 for macropsia group, P = .252 for control group). No eye showed disrupted ELM and IS/OS junction, regardless of the presence of macropsia.
Eyes with macropsia showed thicker foveal ONL, IS/OS/RPE, and more frequently disrupted COST lines. This may indicate that the contractile strength of ERM can lead to centralization of photoreceptor cells. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:656-663.].
基于频域光学相干断层扫描（SD-OCT）评估视网膜前膜（ERM）所致视物显大症患者的视网膜形态学特征。
进行一项横断面、非干预性研究，以比较有或无视物显大症的ERM患者眼部视网膜结构的特征。26例伴有视物显大症的ERM患者被定义为视物显大症组，26例年龄匹配的无视物显大症的ERM患者为对照组。所有参与者均接受了全面的眼科检查和SD-OCT检查。使用双点图表对视物显大症进行诊断和量化。通过SD-OCT系统的电子卡尺测量视网膜各层的厚度，包括中央凹处的外核层（ONL）和内节/外节/视网膜色素上皮（IS/OS/RPE）。计算每位患者各参数的眼间比率，并在两组之间进行比较。评估外界膜（ELM）、IS/OS连接和视锥细胞外节顶端（COST）线的完整性。
视物显大症组双眼的IS/OS/RPE厚度差异有统计学意义（P < .001），而对照组差异无统计学意义（P = .161）。视物显大症组患眼的ONL明显厚于对照组（P = .020），而两组对照眼的ONL厚度差异无统计学意义（P = .860）。视物显大症组有更多患者的COST线中断（视物显大症组P < .001，对照组P = .252）。无论有无视物显大症，均无眼显示ELM和IS/OS连接中断。
伴有视物显大症的眼中央凹ONL、IS/OS/RPE更厚，COST线中断更频繁。这可能表明ERM的收缩力可导致光感受器细胞向心性分布。[《眼科手术、激光与视网膜成像》。2018年；49:656 - 663。]
