Keye Eye Center, Seoul, Korea.
PLoS One. 2021 Jan 7;16(1):e0245063. doi: 10.1371/journal.pone.0245063. eCollection 2021.
The prevalence of epiretinal membrane (ERM) and associated factors in the phakic eyes have not been fully elucidated yet. This cross-sectional study included 2,354 phakic eyes without retinal diseases or surgical history. Ocular parameters, such as uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), intraocular pressure (IOP), white-to-white corneal diameter (WTW), mean keratometric value (Km) of total corneal refractive power at 4-mm diameter (TCRP4), astigmatism of TCRP4, total corneal irregular astigmatism (TCIA), pupil diameter, axial length (AXL), anterior chamber depth (ACD), lens thickness (LT), and posterior vitreous detachment (PVD) were compared between ERM group and control group. Additionally, an age-matched control group was selected by individual matching and compared with the ERM group to eliminate the confounders. Multiple logistic regression analysis was performed to evaluate the factors associated with the presence of ERM. Among 2,354 eyes, 429 eyes (18.2%) had ERM based on spectral-domain optical coherence tomography. The ERM group showed higher prevalence of PVD, worse CDVA, higher astigmatism of TCRP4, higher TCIA, smaller pupil size, longer AXL, and thicker LT than control group (P < 0.001, P < 0.001, P = 0.011, P < 0.001, P = 0.023, P < 0.001, and P < 0.001, respectively). Only PVD, CDVA, SE, astigmatism of TCRP4, TCIA, and AXL maintained the significance when compared with the age-matched control group (P < 0.001, P = 0.026, P < 0.001, P = 0.001, P = 0.003, and P < 0.001, respectively). Multivariate logistic regression analysis showed that age, PVD, CDVA, and TCIA were independently associated with the presence of ERM (P < 0.001, P < 0.001, P = 0.011, and P = 0.002). The prevalence of ERM detected using SD-OCT was 18.2% in the middle aged phakic population. Eyes with TCIA, in addition to older age and PVD, were more likely to have ERM.
在未行手术的眼（即生理性眼）中，内界膜（ERM）的发生率及其相关因素尚未完全阐明。本横断面研究纳入了 2354 例无眼部疾病或手术史的生理性眼。比较了 ERM 组和对照组的眼部参数，包括未矫正远视力（UDVA）、矫正远视力（CDVA）、等效球镜（SE）、眼压（IOP）、角膜直径（WTW）、总角膜屈光力在 4mm 直径处的平均角膜曲率值（TCRP4）、TCRP4 散光、总角膜不规则散光（TCIA）、瞳孔直径、眼轴（AXL）、前房深度（ACD）、晶状体厚度（LT）和后玻璃体脱离（PVD）。此外，通过个体匹配选择了年龄匹配的对照组，并与 ERM 组进行比较，以消除混杂因素。采用多因素逻辑回归分析评估与 ERM 相关的因素。在 2354 只眼中，根据谱域光学相干断层扫描（SD-OCT），429 只眼（18.2%）存在 ERM。ERM 组 PVD 发生率较高、CDVA 较差、TCRP4 散光较高、TCIA 较高、瞳孔较小、AXL 较长、LT 较厚（均 P < 0.001，P < 0.001，P = 0.011，P < 0.001，P = 0.023，P < 0.001，P < 0.001）。与年龄匹配的对照组相比，仅 PVD、CDVA、SE、TCRP4 散光、TCIA 和 AXL 仍具有统计学意义（均 P < 0.001，P = 0.026，P < 0.001，P = 0.001，P = 0.003，P < 0.001）。多因素逻辑回归分析显示，年龄、PVD、CDVA 和 TCIA 与 ERM 的发生独立相关（均 P < 0.001，P < 0.001，P = 0.011，P = 0.002）。SD-OCT 检测到的 ERM 发生率为 18.2%，发生于中年生理性眼。除了年龄较大和 PVD 外，TCIA 较大的眼更有可能发生 ERM。
