van Harten Roel M, van Woudenbergh Esther, van Dijk Albert, Haagsman Henk P
Division Molecular Host Defence, Dept. Infectious diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands.
Vaccines (Basel). 2018 Sep 14;6(3):63. doi: 10.3390/vaccines6030063.
Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions. These effector molecules of the innate immune system of many vertebrates are diverse in their amino acid sequence but share physicochemical characteristics like positive charge and amphipathicity. Besides being antimicrobial, cathelicidins have a wide variety in immunomodulatory functions, both boosting and inhibiting inflammation, directing chemotaxis, and effecting cell differentiation, primarily towards type 1 immune responses. In this review, we will examine the biology and various functions of cathelicidins, focusing on putting in vitro results in the context of in vivo situations. The pro-inflammatory and anti-inflammatory functions are highlighted, as well both direct and indirect effects on chemotaxis and cell differentiation. Additionally, we will discuss the potential and limitations of using cathelicidins as immunomodulatory or antimicrobial drugs.
Cathelicidins是具有抗菌和免疫调节功能的宿主防御肽。许多脊椎动物先天免疫系统的这些效应分子氨基酸序列多样，但具有诸如正电荷和两亲性等物理化学特征。除了具有抗菌作用外，Cathelicidins在免疫调节功能方面具有广泛的多样性，既能促进炎症又能抑制炎症，引导趋化作用，并影响细胞分化，主要是向1型免疫反应方向分化。在本综述中，我们将研究Cathelicidins的生物学特性和各种功能，重点是将体外实验结果置于体内情况的背景下进行考量。突出了其促炎和抗炎功能，以及对趋化作用和细胞分化的直接和间接影响。此外，我们还将讨论使用Cathelicidins作为免疫调节或抗菌药物的潜力和局限性。
