急性相蛋白水平作为诊断反刍动物病毒病的辅助工具——综述
Acute Phase Protein Levels as An Auxiliary Tool in Diagnosing Viral Diseases in Ruminants-A Review.
机构信息
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postepu 36A str., 05-552 Jastrzębiec, Poland.
Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska str. 159c., 02-776 Warsaw, Poland.
出版信息
Viruses. 2018 Sep 15;10(9):502. doi: 10.3390/v10090502.
We examined acute phase protein (APP) concentrations in viral infections of dairy ruminants and assessed the potential role of characteristic patterns of APP changes in auxiliary diagnosing viral diseases. All viruses reviewed are common causes of farm animal diseases. APPs are among the first agents of immunity, and their concentrations could be diagnostically relevant. In the most common ruminant viral diseases, elevated serum amyloid A (SAA) and haptoglobin (Hp) levels in blood serum have been observed. However, since these proteins are the main APPs in many viral infections, it is impossible to use their levels for diagnosing particular infections. Decreased Cp and albumin expression could help differentiate the bluetongue virus infection from other diseases. Lastly, analysis of SAA levels in blood serum and milk could be helpful in diagnosing small ruminant lentivirus infection. While promising, APP levels can only be considered as an auxiliary tool in diagnosing viral diseases in ruminants.
我们研究了反刍动物病毒感染中的急性期蛋白（APP）浓度，并评估了 APP 变化特征在辅助诊断病毒性疾病中的潜在作用。本文中提到的所有病毒都是常见的家畜疾病病原体。APP 是免疫反应的最初介质之一，其浓度可能具有诊断意义。在最常见的反刍动物病毒性疾病中，血清中血清淀粉样蛋白 A（SAA）和触珠蛋白（Hp）的水平升高。然而，由于这些蛋白质是许多病毒感染的主要 APP，因此无法使用它们的水平来诊断特定的感染。Cp 和白蛋白表达的降低有助于将蓝舌病病毒感染与其他疾病区分开来。最后，分析血清和乳中 SAA 水平有助于诊断小反刍动物慢病毒感染。虽然有希望，但 APP 水平只能被视为诊断反刍动物病毒性疾病的辅助工具。
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