Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California San Francisco, California, USA.
Adv Exp Med Biol. 2018;1095:83-100. doi: 10.1007/978-3-319-95693-0_5.
Prostate cancer causes significant morbidity in men and metastatic disease is a major cause of cancer related deaths. Prostate metastasis is controlled by various cellular intrinsic and extrinsic factors, which are often under the regulatory control of various metastasis-associated genes. Given the dynamic nature of metastatic cancer cells, the various factors controlling this process are themselves regulated by microRNAs which are small non-coding RNAs. Significant research work has shown differential microRNA expression in primary and metastatic prostate cancer suggesting their importance in prostate pathogenesis. We will review the roles of different microRNAs in controlling the various steps in prostate metastasis.
前列腺癌给男性带来严重的发病风险，转移性疾病是癌症相关死亡的主要原因。前列腺转移受多种细胞内、外因素的控制，这些因素通常受多种转移相关基因的调控。鉴于转移性癌细胞的动态特性，控制这一过程的各种因素本身也受到 microRNAs 的调控，microRNAs 是一类小型非编码 RNA。大量研究工作表明，原发性和转移性前列腺癌中的 microRNA 表达存在差异，这表明它们在前列腺发病机制中的重要性。我们将综述不同 microRNAs 在控制前列腺转移的各个步骤中的作用。
