Peifer M, Bender W
EMBO J. 1986 Sep;5(9):2293-303. doi: 10.1002/j.1460-2075.1986.tb04497.x.
The anterobithorax (abx) and bithorax (bx) genes together direct the development of the posterior second and anterior third thoracic segments of the fruit fly. We have characterized the phenotypes and DNA lesions of 19 abx and bx alleles. abx and bx mutations differ both in the nature and location of their DNA lesions, forming two clusters within a relatively small region of the Ultrabithorax transcription unit. Correlation between phenotype and DNA lesion suggests the presence of two or more genetic elements in this region distinct from the Ultrabithorax transcript. Mutant transformations do not strictly obey segmental or parasegmental boundaries. Most of the bx mutations result from insertions of the mobile element gypsy. The strength of these alleles varies in a regular way dependent on the position and orientation of the gypsy element. We propose models for gypsy element action and bithorax complex expression in the light of these results.
前胸部（abx）和双胸（bx）基因共同指导果蝇第二胸节后段和第三胸节前段的发育。我们已经对19个abx和bx等位基因的表型和DNA损伤进行了表征。abx和bx突变在其DNA损伤的性质和位置上都有所不同，在超双胸转录单元的一个相对较小区域内形成两个簇。表型与DNA损伤之间的相关性表明，该区域存在两个或更多与超双胸转录本不同的遗传元件。突变转化并不严格遵循节段或副节段边界。大多数bx突变是由移动元件gypsy的插入引起的。这些等位基因的强度根据gypsy元件的位置和方向以规则的方式变化。根据这些结果，我们提出了gypsy元件作用和双胸复合体表达的模型。
