Numazaki K, Chiba S, Kogawa K, Umetsu M, Motoya H, Nakao T
Eur J Clin Microbiol. 1986 Oct;5(5):573-5. doi: 10.1007/BF02017708.
Serum immunoglobulin M (IgM) antibodies to Chlamydia trachomatis and to human cytomegalovirus (CMV) were detected by enzyme-linked fluorescence assay and enzyme-linked immunosorbent assay, respectively in 19 premature infants with chronic lung diseases, in 43 extremely low birth weight premature infants and in 123 neonates with elevated serum IgM levels. Ten of the 19 premature infants with chronic lung diseases had elevated serum IgM levels, and five had IgM antibodies to Chlamydia trachomatis. Three of the 43 extremely low birth weight premature infants had elevated serum IgM levels, and two had IgM antibodies to Chlamydia trachomatis. Three of the 123 neonates with elevated serum IgM levels (excluding those with chronic lung diseases and extremely low birth weight) had IgM antibodies to CMV. These results suggest that chronic lung diseases in low birth weight infants might be caused by intrauterine Chlamydia trachomatis infection.
分别采用酶联荧光分析法和酶联免疫吸附测定法，检测了19例患有慢性肺部疾病的早产儿、43例极低出生体重早产儿以及123例血清免疫球蛋白M（IgM）水平升高的新生儿血清中抗沙眼衣原体和抗人巨细胞病毒（CMV）的IgM抗体。19例患有慢性肺部疾病的早产儿中，10例血清IgM水平升高，5例有抗沙眼衣原体的IgM抗体。43例极低出生体重早产儿中，3例血清IgM水平升高，2例有抗沙眼衣原体的IgM抗体。123例血清IgM水平升高的新生儿（不包括患有慢性肺部疾病和极低出生体重的新生儿）中，3例有抗CMV的IgM抗体。这些结果表明，低出生体重儿的慢性肺部疾病可能由宫内沙眼衣原体感染引起。
