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迈向艾滋病规划署 90-90-90 目标的进展:乌干达坎帕拉的女性性工作者中的一项应答驱动调查。

Progress toward UNAIDS 90-90-90 targets: A respondent-driven survey among female sex workers in Kampala, Uganda.

机构信息

Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

出版信息

PLoS One. 2018 Sep 19;13(9):e0201352. doi: 10.1371/journal.pone.0201352. eCollection 2018.

Abstract

BACKGROUND

We investigated progress towards UNAIDS 90-90-90 targets among female sex workers in Kampala, Uganda, who bear a disproportionate burden of HIV.

METHODS

Between April and December 2012, 1,487 female sex workers, defined as women, 15-49 years, residing in greater Kampala, and selling sex for money in the last 6 months, were recruited using respondent-driven sampling. Venous blood was collected for HIV and viral load testing [viral load suppression (VLS) defined as <1,000 copies/mL]. We collected data using audio computer-assisted self-interviews and calculated weighted population-level estimates.

RESULTS

The median age was 27 years (interquartile range: 23 to 32). HIV seroprevalence was 31.4% (95% confidence interval [CI]: 29.0, 33.7%). Among all female sex workers who tested HIV-positive in the survey (population-level targets), 45.5% (95% CI: 40.1, 51.0) had knowledge of their serostatus (population-level target: 90%), 37.8% (95% CI: 32.2, 42.8) self-reported to be on ART (population-level target: 81%), and 35.2% (95% CI: 20.7, 30.4) were virally suppressed (population-level target: 73%).

CONCLUSIONS

HIV prevalence among Kampala female sex workers is high, whereas serostatus knowledge and VLS are far below UNAIDS targets. Kampala female sex workers are in need of intensified and targeted HIV prevention and control efforts.

摘要

背景

我们研究了乌干达坎帕拉的女性性工作者在实现 UNAIDS 90-90-90 目标方面的进展,这些女性性工作者承担着不成比例的 HIV 负担。

方法

在 2012 年 4 月至 12 月期间,使用回应者驱动抽样法招募了 1487 名女性性工作者,这些女性性工作者定义为年龄在 15-49 岁之间、居住在大坎帕拉地区、并且在过去 6 个月内以金钱为目的进行性交易的女性。采集静脉血进行 HIV 和病毒载量检测[病毒载量抑制(VLS)定义为 <1000 拷贝/ml]。我们使用音频计算机辅助自我访谈收集数据,并计算加权的人群水平估计值。

结果

中位年龄为 27 岁(四分位间距:23 至 32)。HIV 血清流行率为 31.4%(95%置信区间:29.0,33.7%)。在所有在调查中 HIV 检测呈阳性的女性性工作者中(人群水平目标),45.5%(95%置信区间:40.1,51.0)知晓自己的血清状况(人群水平目标:90%),37.8%(95%置信区间:32.2,42.8)自我报告正在接受抗逆转录病毒治疗(人群水平目标:81%),35.2%(95%置信区间:20.7,30.4)病毒得到抑制(人群水平目标:73%)。

结论

坎帕拉女性性工作者的 HIV 流行率很高,而血清学知晓率和病毒抑制率远低于 UNAIDS 目标。坎帕拉的女性性工作者需要加强和有针对性的 HIV 预防和控制工作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee42/6145590/c90a25f781de/pone.0201352.g001.jpg

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