Wuxi Center for Disease Control and Prevention, Wuxi, 214023, Jiangsu, China.
Jiangsu Center for Disease Control and Prevention, Nanjing, 210009, Jiangsu, China.
BMC Infect Dis. 2018 Sep 19;18(1):472. doi: 10.1186/s12879-018-3385-1.
Hand, foot, and mouth disease (HFMD) is a viral disease caused by human enteroviruses. Although HFMD reinfection is common, studies investigating this phenomenon are insufficient.
The present study focused on HFMD reinfection in Wuxi from 2008 to 2016 using surveillance system data.
Of 107,677 cases included in the study, 6470 cases were classified as reinfections. The overall reinfection rate was 6.01% (6.37% male and 5.48% female patients), which decreased with increasing age (χ = 1125.477, p < 0.001). The rate was 6.17 and 5.79% in urban and rural areas, respectively, and 7.83 and 5.98% of the cases were severe and mild, respectively. Multivariate logistic regression analysis showed that male sex, younger age, residence in an urban area, and severe disease were risk factors for HFMD reinfection. The case-severity rate in secondary infection cases was lower than that in non-reinfection cases (odds ratio 0.675, 95% confidence interval 0.526-0.866).
Boys younger than 4 years of age living in urban areas were more prone to reinfection. Specific health education and intervention should be developed to protect these susceptible populations.
手足口病（HFMD）是由人类肠道病毒引起的病毒性疾病。尽管 HFMD 再感染很常见，但对此现象的研究还不够充分。
本研究使用监测系统数据，聚焦于 2008 年至 2016 年期间无锡的 HFMD 再感染情况。
在纳入研究的 107677 例病例中，有 6470 例被归类为再感染。总再感染率为 6.01%（男性 6.37%，女性 5.48%），随年龄增长而降低（χ²=1125.477，p<0.001）。城市和农村地区的再感染率分别为 6.17%和 5.79%，重症和轻症的再感染率分别为 7.83%和 5.98%。多因素 logistic 回归分析显示，男性、年龄较小、居住在城区以及重症是 HFMD 再感染的危险因素。二次感染病例的严重程度发生率低于非再感染病例（比值比 0.675，95%置信区间 0.526-0.866）。
4 岁以下居住在城区的男孩更容易再感染。应制定特定的健康教育和干预措施来保护这些易感人群。
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