微生物群与衰老。

Microbiota and Aging.

机构信息

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.

School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.

出版信息

Adv Exp Med Biol. 2018;1086:141-156. doi: 10.1007/978-981-13-1117-8_9.

DOI:10.1007/978-981-13-1117-8_9

PMID:30232757

Abstract

The human gut microbiota is a huge ecosystem that provides lots of functions for host development, immune system, and metabolism. Gut microbiota is linked to lots of diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), irritable bowel syndrome, and cardiovascular disease (CVD). Few studies, however, have noted the relationship between aging and microbiota; the connection between aging and microbiota remains largely to be researched. In this review, recent research findings are summarized on the role of gut microbiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in antiaging medicine.

摘要

人类肠道微生物群是一个巨大的生态系统，为宿主的发育、免疫系统和新陈代谢提供了许多功能。肠道微生物群与许多疾病有关，包括人类代谢疾病，如肥胖、2 型糖尿病（T2D）、肠易激综合征和心血管疾病（CVD）。然而，很少有研究注意到衰老和微生物群之间的关系；衰老和微生物群之间的联系在很大程度上仍有待研究。在这篇综述中，总结了肠道微生物群在衰老过程中的作用的最新研究发现，重点介绍了针对微生物组的干预措施在抗衰老医学中的治疗潜力。