化妆品中生育酚和生育三烯酚的安全性评估。

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics.

作者信息

Fiume Monice M, Bergfeld Wilma F, Belsito Donald V, Hill Ronald A, Klaassen Curtis D, Liebler Daniel C, Marks James G, Shank Ronald C, Slaga Thomas J, Snyder Paul W, Andersen F Alan, Heldreth Bart

机构信息

1 Cosmetic Ingredient Review Senior Director, Cosmetic Ingredient Review, Washington, DC, USA .

2 Cosmetic Ingredient Review Expert Panel Member, Cosmetic Ingredient Review, Washington, DC, USA.

出版信息

Int J Toxicol. 2018 Sep/Oct;37(2_suppl):61S-94S. doi: 10.1177/1091581818794455.

DOI:10.1177/1091581818794455

PMID:30235959

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.

摘要

化妆品成分审查（CIR）专家小组评估了14种生育酚和生育三烯酚的安全性，得出结论：这些成分在化妆品中的使用是安全的。据报道，生育酚在化妆品中起抗氧化剂或皮肤调理剂的作用；相比之下，生育三烯酚在化妆品中据报道不是作为抗氧化剂起作用，而是作为光稳定剂、口腔护理剂或皮肤调理剂。专家小组审查了新的和现有的动物及临床数据，以确定这些成分的安全性，并认为将现有信息外推以得出所有生育酚和生育三烯酚的安全性结论是合适的。