Center for Intelligent Drug Delivery and Sensing Using microcontainers and Nanomechanics (IDUN), Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark.
Center for Nanomedicine and Theranostics, Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark.
Adv Drug Deliv Rev. 2019 Jan 1;138:41-55. doi: 10.1016/j.addr.2018.09.005. Epub 2018 Sep 17.
Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids, as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these), towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance. Also, a proof-of-concept depicting 'microbots-in-a-capsule' towards oral drug delivery has been discussed.
自主推进/外部引导的微型马达通过提供 (a) 更高的药物装载能力、(b) 局部递送（更少的毒性）、(c) 增强的组织穿透和 (d) 体内主动机动来克服当前的药物输送挑战。这些微尺度药物输送系统可以利用生物流体以及外部刺激，如光-NIR、超声和磁场（或这些的组合）来推动/药物释放。这些无线药物载体对局部靶向和控制药物释放的能力，使它们成为在复杂微环境（如实体瘤或胃肠道）中进行药物给药的有吸引力的候选者。在本报告中，我们讨论了这些微尺度药物输送系统在体内环境下的治疗益处，并提供了一个设计-应用原理，以实现更大的临床意义。此外，还讨论了一个概念验证，描述了“胶囊中的微型机器人”在口服药物输送方面的应用。
