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Screening for childhood adversity: the what and when of identifying individuals at risk for lifespan health disparities.儿童期逆境筛查：识别有终生健康差异风险个体的内容和时机。
J Behav Med. 2018 Aug;41(4):516-527. doi: 10.1007/s10865-018-9921-z. Epub 2018 Mar 30.
2
Continuing conversations about adverse childhood experiences (ACEs) screening: A public health perspective.持续探讨不良童年经历（ACEs）筛查：从公共卫生角度。
Child Abuse Negl. 2018 Nov;85:180-184. doi: 10.1016/j.chiabu.2018.03.007. Epub 2018 Mar 17.
3
Using path analysis to examine the relationship between sexual abuse in childhood and diabetes in adulthood in a sample of US adults.使用路径分析方法，在美国成年人样本中研究儿童期性虐待与成年后患糖尿病之间的关系。
Prev Med. 2018 Mar;108:1-7. doi: 10.1016/j.ypmed.2017.12.013. Epub 2017 Dec 22.
4
The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis.多种不良童年经历对健康的影响：系统评价和荟萃分析。
Lancet Public Health. 2017 Aug;2(8):e356-e366. doi: 10.1016/S2468-2667(17)30118-4. Epub 2017 Jul 31.
5
2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断： 。
Diabetes Care. 2018 Jan;41(Suppl 1):S13-S27. doi: 10.2337/dc18-S002.
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Relationship between individual categories of adverse childhood experience and diabetes in adulthood in a sample of US adults: Does it differ by gender?美国成年人样本中个体不良童年经历类别与成年期糖尿病的关系：性别差异如何？
J Diabetes Complications. 2018 Feb;32(2):139-143. doi: 10.1016/j.jdiacomp.2017.11.005. Epub 2017 Nov 11.
7
Methods to Assess Adverse Childhood Experiences of Children and Families: Toward Approaches to Promote Child Well-being in Policy and Practice.评估儿童和家庭不良童年经历的方法：促进政策和实践中儿童福祉的方法。
Acad Pediatr. 2017 Sep-Oct;17(7S):S51-S69. doi: 10.1016/j.acap.2017.04.161.
8
Screening for adverse childhood experiences (ACEs): Cautions and suggestions.筛查不良儿童经历（ACEs）：注意事项和建议。
Child Abuse Negl. 2018 Nov;85:174-179. doi: 10.1016/j.chiabu.2017.07.016. Epub 2017 Aug 4.
9
Childhood Maltreatment Is an Independent Risk Factor for Prediabetic Disturbances in Glucose Regulation.童年期受虐是血糖调节前驱糖尿病紊乱的独立危险因素。
Front Endocrinol (Lausanne). 2017 Jun 30;8:151. doi: 10.3389/fendo.2017.00151. eCollection 2017.
10
Adverse Childhood Experiences: Survey of Resident Practice, Knowledge, and Attitude.童年不良经历：住院医师实践、知识与态度调查
Fam Med. 2017 Jan;49(1):7-13.

美国成年人纵向队列研究中，不良童年经历对糖尿病前期发展的差异影响。

The differential impact of adverse childhood experiences in the development of pre-diabetes in a longitudinal cohort of US adults.

机构信息

Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; University of Wisconsin, Milwaukee, Joseph Zilber School of Public Health, 1240 N 10th Street, Milwaukee, WI 53205, USA.

Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.

出版信息

J Diabetes Complications. 2018 Nov;32(11):1018-1024. doi: 10.1016/j.jdiacomp.2018.09.006. Epub 2018 Sep 15.

DOI:10.1016/j.jdiacomp.2018.09.006
PMID:30236541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7553202/
Abstract

BACKGROUND

ACEs have a dose-response relationship with diabetes. The relationship between ACEs and pre-diabetes is not well known and may represent an effective area for prevention efforts.

METHODS

Data from 1054 participants from two waves of the longitudinal MIDUS study were used. Multivariate general linear regression models assessed the relationship between ACEs and biomarker outcomes. Correlation tests and mediation models investigated the relationship between ACE and pre-diabetes.

RESULTS

Individuals reporting ACEs were statistically significantly more likely to have higher BMI (1.13 (0.34-1.92)), higher waist circumference (2.74 (0.72-4.76)), elevated blood fasting insulin levels (2.36 (0.71-4.02)) and higher insulin resistance (HOMA-IR (0.57 (0.08-1.06)). BMI/waist circumference and insulin resistance did not maintain independent relationships with ACEs once HOMA-IR was included in the dichotomized ACE model (p = 0.05 and p = 0.06, respectively), suggesting the relationship between BMI and ACEs may be mediated by insulin resistance.

CONCLUSIONS

These results represent one of the first studies to examine the differential impact of ACEs on a diverse set of clinical pre-diabetes measures. Findings suggest sexual and physical abuse, and financial strain during childhood are important factors associated with higher risk for pre-diabetes, and should be considered during intervention development.

摘要

背景

逆境经历与糖尿病存在剂量反应关系。逆境经历与糖尿病前期的关系尚不清楚，这可能是预防工作的一个有效领域。

方法

使用来自纵向 MIDUS 研究两个波次的 1054 名参与者的数据。多变量一般线性回归模型评估了逆境经历与生物标志物结果之间的关系。相关检验和中介模型研究了逆境经历与糖尿病前期之间的关系。

结果

报告有逆境经历的个体在统计学上更有可能具有更高的 BMI（1.13（0.34-1.92））、更高的腰围（2.74（0.72-4.76））、更高的空腹胰岛素水平（2.36（0.71-4.02））和更高的胰岛素抵抗（HOMA-IR（0.57（0.08-1.06））。在将 HOMA-IR 纳入二分 ACE 模型后，BMI/腰围和胰岛素抵抗与 ACE 不再保持独立关系（p=0.05 和 p=0.06），这表明 BMI 与 ACE 之间的关系可能通过胰岛素抵抗来介导。

结论

这些结果代表了首批研究之一，旨在检查逆境经历对一系列不同的临床糖尿病前期指标的不同影响。研究结果表明，童年时期的性虐待和身体虐待以及经济压力是与糖尿病前期风险增加相关的重要因素，在制定干预措施时应予以考虑。