The Mount Sinai ICAHN School of Medicine, New York, New York, USA.
Clin Pharmacol Ther. 2019 Jan;105(1):36-38. doi: 10.1002/cpt.1235. Epub 2018 Oct 29.
Skin is an efficient protective barrier armed with an intricate network of antioxidants. External environmental stress diminishes and sometimes overwhelms these innate protective mechanisms; aging slows their efficacy. Topical antioxidants enhance natural endogenous defenses to create an indwelling reservoir for sustained protection with far higher concentrations than possible with oral intake. The challenge is creating formulations of these labile molecules that are stable, active, and can be effectively absorbed transdermally to deliver high concentrations.
皮肤是一种高效的保护屏障，拥有复杂的抗氧化剂网络。外部环境压力会削弱甚至有时会破坏这些先天的保护机制；而衰老则会降低它们的功效。局部抗氧化剂可以增强天然内在防御能力，形成内在储库，从而实现持续保护，其浓度远高于口服摄入的可能浓度。挑战在于如何制备这些不稳定的分子的配方，使其稳定、有效，并能有效地经皮吸收，以达到高浓度。
