College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Autonomous Region, Hohhot, China.
Sci Rep. 2018 Sep 21;8(1):14227. doi: 10.1038/s41598-018-31986-2.
It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genes CHP1, SMAD2, FZD6 and SIAH1.
人们普遍认为，毛囊的周期性循环受生物钟控制，但毛囊周期的分子调节机制尚未得到深入研究。山羊绒次级毛囊的特征是一生中具有季节性周期性变化。在毛囊周期中，毛囊的启动对于毛囊再生具有重要意义。为了为毛囊研究提供参考，我们的研究比较了山羊绒皮肤样本生长和休止阶段的 mRNA 表达和 microRNA 表达差异。通过 microRNA 和 mRNA 关联分析，我们发现了在毛囊启动中起主要调节作用的 microRNAs 和靶基因。我们进一步构建了 mRNA-microRNA 相互作用网络，发现毛囊的启动和发育与 MiR-195 以及 CHP1、SMAD2、FZD6 和 SIAH1 基因有关。
