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部分氧化的银/金纳米颗粒对口腔病原菌W83的抗菌活性

Antibacterial Activity of Partially Oxidized Ag/Au Nanoparticles against the Oral Pathogen W83.

作者信息

Holden Megan S, Black Jason, Lewis Ainsely, Boutrin Marie-Claire, Walemba Elvin, Sabir Theodore S, Boskovic Danilo S, Wilson Aruni, Fletcher Hansel M, Perry Christopher C

机构信息

Division of Biochemistry, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.

Northern Caribbean University, Manchester, Jamaica.

出版信息

J Nanomater. 2016;2016. doi: 10.1155/2016/9605906.

DOI:10.1155/2016/9605906
PMID:30245705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6146971/
Abstract

Advances in nanotechnology provide opportunities for the prevention and treatment of periodontal disease. While physicochemical properties of Ag containing nanoparticles (NPs) are known to influence the magnitude of their toxicity, it is thought that nanosilver can be made less toxic to eukaryotes by passivation of the NPs with a benign metal. Moreover, the addition of other noble metals to silver nanoparticles, in the alloy formulation, is known to alter the silver dissolution behavior. Thus, we synthesized glutathione capped Ag/Au alloy bimetallic nanoparticles (NPs) the galvanic replacement reaction between maltose coated Ag NPs and chloroauric acid (HAuCl) in 5% aqueous triblock F127 copolymer solution. We then compared the antibacterial activity of the Ag/Au NPs to pure Ag NPs on W83, a key pathogen in the development of periodontal disease. Only partially oxidized glutathione capped Ag and Ag/Au (Au:Ag≈0.2) NPs inhibited the planktonic growth of W83. This effect was enhanced in the presence of hydrogen peroxide, which simulates the oxidative stress environment in the periodontal pocket during chronic inflammation.

摘要

纳米技术的进步为牙周疾病的预防和治疗提供了机遇。虽然含银纳米颗粒（NPs）的物理化学性质已知会影响其毒性大小，但人们认为通过用良性金属对纳米银进行钝化处理，可以降低其对真核生物的毒性。此外，在合金配方中向银纳米颗粒添加其他贵金属，已知会改变银的溶解行为。因此，我们在5%的三嵌段F127共聚物水溶液中，通过麦芽糖包覆的银纳米颗粒与氯金酸（HAuCl）之间的电化置换反应，合成了谷胱甘肽包覆的Ag/Au合金双金属纳米颗粒（NPs）。然后，我们将Ag/Au NPs与纯银纳米颗粒对W83（牙周疾病发展中的一种关键病原体）的抗菌活性进行了比较。只有部分氧化的谷胱甘肽包覆的银和Ag/Au（Au:Ag≈0.2）NPs抑制了W83的浮游生长。在过氧化氢存在的情况下，这种效果会增强，过氧化氢模拟了慢性炎症期间牙周袋中的氧化应激环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762d/6146971/0d15eaadfc72/nihms-942705-f0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762d/6146971/2d6673c5d851/nihms-942705-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/762d/6146971/0d15eaadfc72/nihms-942705-f0007.jpg

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