Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Clin Transl Gastroenterol. 2018 Sep 24;9(9):188. doi: 10.1038/s41424-018-0054-z.
Inflammatory bowel diseases (IBD) and asthma share genetic and environmental risk factors. Consequently, several observational studies have explored an association between IBD and asthma. We systematically reviewed and summarized the literature on the co-occurrence of asthma and IBD.
MEDLINE and EMBASE (to April 2017) were searched to identify observational studies on the association between asthma and IBD. Relative risks (RR) were pooled using random effects models. Heterogeneity was assessed using the I and Cochran Q statistics. Meta-regression based on study design, source of patients (population-based vs. tertiary-care center) and study location was conducted to explain between-study heterogeneity.
Eighteen studies were identified (15 Crohn's disease, 15 ulcerative colitis (UC)). Asthma was associated with both Crohn's disease (pooled RR 1.30, 95% confidence interval (CI) 1.16-1.47, I = 88%) and UC (RR 1.34, 95% CI 1.24-1.44, I = 93%). The study design and source of patients and study location explained between-study heterogeneity in Crohn's disease, but not UC.
Asthma is associated with both Crohn's disease and UC. Additional research is needed to determine if one disease influences the risk of developing the other or if the frequent co-occurrence of these diseases result from shared genetic, environmental, and microbial risk factors.
炎症性肠病（IBD）和哮喘具有共同的遗传和环境风险因素。因此，一些观察性研究已经探讨了 IBD 和哮喘之间的关联。我们系统地回顾和总结了关于哮喘和 IBD 同时发生的文献。
检索 MEDLINE 和 EMBASE（截至 2017 年 4 月），以确定关于哮喘和 IBD 相关性的观察性研究。使用随机效应模型汇总相对风险（RR）。使用 I 和 Cochran Q 统计量评估异质性。基于研究设计、患者来源（基于人群与三级保健中心）和研究地点进行基于元回归的分析，以解释研究间的异质性。
确定了 18 项研究（15 项克罗恩病，15 项溃疡性结肠炎（UC））。哮喘与克罗恩病（汇总 RR 1.30，95%置信区间（CI）1.16-1.47，I = 88%）和 UC（RR 1.34，95%CI 1.24-1.44，I = 93%）均相关。研究设计、患者来源和研究地点解释了克罗恩病中的研究间异质性，但 UC 中则不然。
哮喘与克罗恩病和 UC 均相关。需要进一步的研究来确定一种疾病是否会影响另一种疾病的发病风险，或者这些疾病的频繁同时发生是否是由于共同的遗传、环境和微生物风险因素所致。
