Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; Biotechnologisches Zentrum, Technische Universität Dresden, Tatzberg 47/49, 01309 Dresden, Germany.
Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Technische Universität Dresden, Fetscher Strasse 74, 01307 Dresden, Germany; German Center for Diabetes Research (DZD e.V.), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.
Dev Cell. 2018 Sep 24;46(6):781-793.e4. doi: 10.1016/j.devcel.2018.05.028.
How cold-blooded animals acclimate to temperature and what determines the limits of their viable temperature range are not understood. Here, we show that Drosophila alter their dietary preference from yeast to plants when temperatures drop below 15°C and that the different lipids present in plants improve survival at low temperatures. We show that Drosophila require dietary unsaturated fatty acids present in plants to adjust membrane fluidity and maintain motor coordination. Feeding on plants extends lifespan and survival for many months at temperatures consistent with overwintering in temperate climates. Thus, physiological alterations caused by a temperature-dependent dietary shift could help Drosophila survive seasonal temperature changes.
冷血动物如何适应温度以及决定其可行温度范围极限的因素尚不清楚。在这里，我们表明，当温度降至 15°C 以下时，果蝇会改变其从酵母到植物的饮食偏好，而植物中存在的不同脂质可以提高其在低温下的存活率。我们表明，果蝇需要植物中存在的膳食不饱和脂肪酸来调节膜流动性并维持运动协调。以植物为食可以延长寿命，并在与温带地区越冬一致的温度下存活数月。因此，由温度依赖性饮食变化引起的生理变化可能有助于果蝇适应季节性温度变化。
