短期和长期运动对大鼠脑出血后运动功能恢复的行为学影响
Behavioral Effect of Short- and Long-Term Exercise on Motor Functional Recovery after Intracerebral Hemorrhage in Rats.
作者信息
Tamakoshi Keigo, Ishida Kazuto, Hayao Keishi, Takahashi Hideaki, Tamaki Hiroyuki
机构信息
Department of Physical Therapy, Niigata University of Health and Welfare, Niigata, Japan; Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata, Japan.
Department of Physical Therapy, Toyohashi Sozo University, Toyohashi, Japan; Department of Physical Therapy, Nagoya University Graduation School of Medicine, Nagoya, Japan.
出版信息
J Stroke Cerebrovasc Dis. 2018 Dec;27(12):3630-3635. doi: 10.1016/j.jstrokecerebrovasdis.2018.08.038. Epub 2018 Sep 22.
BACKGROUND
In this study, we investigated the effects of short- and long-term exercise on motor functional recovery following intracerebral hemorrhage (ICH) in rats.
METHODS
Male Wistar rats were randomly divided into 5 experimental groups: ICH without training (ICH group), ICH with long-term exercise for 14days from the second day after surgery (ICH + LT group), ICH with short-term exercise for 7days from the second day after surgery (ICH + EST group), ICH with short-term exercise for 7days from the ninth day after surgery (ICH + LST group), and sham operation without training (SHAM group). ICH was induced by collagenase injection into the left striatum. Forelimb sensorimotor function was evaluated using forelimb placing and horizontal ladder tests.
RESULTS
In the behavioral test, the ICH + LT and ICH + EST groups improved significantly compared with the ICH and ICH + LT groups. The ICH + LT and ICH + EST groups recovered motor function in an almost analogous pattern.
CONCLUSIONS
Our results indicated that, when exercise was started from an early phase after ICH, both short- and long-term exercises had similar benefits on motor functional recovery. However, continuous training using simple treadmill running may have limitations to motor functional recovery.
背景
在本研究中，我们调查了短期和长期运动对大鼠脑出血（ICH）后运动功能恢复的影响。
方法
将雄性Wistar大鼠随机分为5个实验组：未训练的ICH组（ICH组）、术后第二天开始进行14天长期运动的ICH组（ICH + LT组）、术后第二天开始进行7天短期运动的ICH组（ICH + EST组）、术后第九天开始进行7天短期运动的ICH组（ICH + LST组）以及未训练的假手术组（SHAM组）。通过向左侧纹状体注射胶原酶诱导脑出血。使用前肢放置和水平阶梯试验评估前肢感觉运动功能。
结果
在行为测试中，ICH + LT组和ICH + EST组与ICH组和ICH + LST组相比有显著改善。ICH + LT组和ICH + EST组以几乎相似的模式恢复运动功能。
结论
我们的结果表明，当在脑出血后早期开始运动时，短期和长期运动对运动功能恢复具有相似的益处。然而，使用简单的跑步机跑步进行持续训练可能对运动功能恢复有局限性。
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