Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Int J Geriatr Psychiatry. 2017 Mar;32(3):324-330. doi: 10.1002/gps.4475. Epub 2016 Apr 5.
Personality affects an individual's ability to cope with the burden of chronic disease. However, the impact of personality on quality of life (QoL) in Parkinson's disease (PD) is not well characterized. The goal of this study is to determine the effect of personality on QoL in PD.
The study included 92 patients with idiopathic PD from Baltimore-Washington area movement disorder neurology clinics. QoL was assessed using the 37-item Parkinson's disease Quality of Life Questionnaire (PDQL) total score, and the Neuroticism-Extraversion-Openness Inventory was used to determine personality traits.
Step-wise regression models examined the contribution of personality, depression, demographic, and PD variables on PDQL-assessed QoL. Neuroticism, conscientiousness, years of education, and depression explained 42% of the variance in the PDQL total score after adjusting for other disease variables. High neuroticism (β = -0.727, 95% confidence interval (CI) -1.125, -0.328, p < 0.0001) and depression (β = -9.058, 95%CI -17.46, -0.657, p = 0.035) negatively affected the PDQL, while high conscientiousness (β = 0.468, 95%CI 0.078, 0.858, p = 0.019), and years of education (β = 1.441, 95%CI 0.371, 2.510, p = 0.009) were positive factors.
Personality can have a positive or negative influence on QoL in PD. PD patients with otherwise similar disease burdens and depressive symptoms may experience different levels of QoL depending on the level of neurotic or conscientious personality traits. Therefore, when interpreting patient responses on the PDQL, it is important to understand whether they reflect aspects of PD, that is, motor impairment and depression, which are amenable to treatment or whether they reflect personality traits.
人格会影响个体应对慢性病负担的能力。然而，人格对帕金森病（PD）患者生活质量（QoL）的影响尚不清楚。本研究旨在确定人格对 PD 患者 QoL 的影响。
本研究纳入了来自巴尔的摩-华盛顿地区运动障碍神经病学诊所的 92 名特发性 PD 患者。使用 37 项帕金森病生活质量问卷（PDQL）总分评估 QoL，使用神经质-外向性-开放性人格量表（NEO-FFI）确定人格特征。
逐步回归模型考察了人格、抑郁、人口统计学和 PD 变量对 PDQL 评估的 QoL 的贡献。神经质、尽责性、受教育年限和抑郁在调整其他疾病变量后解释了 PDQL 总分 42%的方差。高神经质（β=-0.727，95%置信区间（CI）-1.125，-0.328，p<0.0001）和抑郁（β=-9.058，95%CI-17.46，-0.657，p=0.035）对 PDQL 有负面影响，而高尽责性（β=0.468，95%CI 0.078，0.858，p=0.019）和受教育年限（β=1.441，95%CI 0.371，2.510，p=0.009）是积极因素。
人格对 PD 患者的 QoL 既有积极影响，也有消极影响。具有类似疾病负担和抑郁症状的 PD 患者可能会因神经质或尽责人格特质的不同而经历不同水平的 QoL。因此，在解释 PDQL 上患者的反应时，重要的是要了解他们的反应是否反映了 PD 的方面，即运动障碍和抑郁，这些方面是可以治疗的，还是反映了人格特质。
