用于慢性耳鸣的经皮迷走神经刺激中刺激强度的特征
Characteristics of Stimulus Intensity in Transcutaneous Vagus Nerve Stimulation for Chronic Tinnitus.
作者信息
Suk Won Choi, Kim Su Jin, Chang Dong Sik, Lee Ho Yun
机构信息
Department of Thoracic Surgery, Eulji University School of Medicine, Daejeon, Korea, Republic Of.
Department of Otolaryngology-Head and Neck Surgery, Eulji University School of Medicine, Daejeon, Korea, Republic Of.
出版信息
J Int Adv Otol. 2018 Aug;14(2):267-272. doi: 10.5152/iao.2018.3977.
OBJECTIVES
We aimed to assess the clinical significance of the intensity of transcutaneous vagus nerve stimulation (tVNS) in chronic tinnitus.
MATERIALS AND METHODS
Four sessions of tVNS were performed over a 2-week period for 24 patients with unilateral, non-pulsatile chronic tinnitus. The cavum, cymba, and tragus were sequentially stimulated to the maximal sensory thresholds. One month later, after the four sessions, the level of tinnitus distress and changes in stimulus intensity were assessed.
RESULTS
The stimulus intensity did not differ according to sex or laterality. However, a moderate positive correlation between tinnitus distress and the initial stimulus intensity was observed. This correlation was not observed during the subsequent sessions. The stimulus intensity at the cavum changed significantly (p=0.018), and notable differences in tinnitus annoyance were observed between the responders and non-responders (p=0.006).
CONCLUSION
The effect of stimulus intensity on the treatment outcome seems to be limited. An increasing trend in the stimulus intensity for tinnitus annoyance at the cavum was observed in the responders. Therefore, the cavum may be an optimal stimulation site for tVNS.
目的
我们旨在评估经皮迷走神经刺激（tVNS）强度在慢性耳鸣中的临床意义。
材料与方法
对24例单侧、非搏动性慢性耳鸣患者在2周内进行了4次tVNS治疗。依次刺激耳甲腔、耳甲艇和耳屏至最大感觉阈值。4次治疗1个月后，评估耳鸣困扰程度和刺激强度变化。
结果
刺激强度在性别或耳鸣侧别上无差异。然而，观察到耳鸣困扰与初始刺激强度之间存在中度正相关。在随后的治疗中未观察到这种相关性。耳甲腔处的刺激强度有显著变化（p = 0.018），反应者与无反应者之间在耳鸣烦恼程度上存在显著差异（p = 0.006）。
结论
刺激强度对治疗结果的影响似乎有限。在反应者中观察到耳甲腔处耳鸣烦恼的刺激强度呈上升趋势。因此，耳甲腔可能是tVNS的最佳刺激部位。
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