生物催化合成内酯和内酰胺。
Biocatalytic synthesis of lactones and lactams.
机构信息
Department of Biotechnology, Delft University of Technology, The Netherlands.
Department of Engineering, Biological and Chemical Engineering, Aarhus University, Denmark.
出版信息
Chem Asian J. 2018 Dec 4;13(23):3601-3610. doi: 10.1002/asia.201801180. Epub 2018 Oct 18.
Cyclic esters and amides (lactones and lactams) are important active ingredients and polymer building blocks. In recent years, numerous biocatalytic methods for their preparation have been developed including enzymatic and chemoenzymatic Baeyer-Villiger oxidations, oxidative lactonisation of diols, and reductive lactonisation and lactamisation of ketoesters. The current state of the art of these methods is reviewed.
环状酯和酰胺（内酯和内酰胺）是重要的活性成分和聚合物构建块。近年来，已经开发出许多用于制备它们的生物催化方法，包括酶和化学酶法 Baeyer-Villiger 氧化、二醇的氧化内酯化、以及酮酯的还原内酯化和内酰胺化。本文综述了这些方法的最新进展。
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